Effect of Electroacupuncture at Zusanli (ST36) on Sepsis Induced by Cecal Ligation Puncture and Its Relevance to Spleen
Joint Authors
Xie, Dong-ping
Mai, Shu-tao
Weng, Yan-na
Du, Jiong-dong
Han, Yun
Zhou, Geng-biao
Chen, Rui-lan
Qin, Xiao-lian
Lai, Fang
Zhang, Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Acupuncture at Zusanli (ST36), Quchi (LI11), and Tianshu (ST25) is commonly used in septic patients by traditional Chinese physicians.
The protective effect of acupuncture at ST36 on the intestinal barrier is associated with Cholinergic Anti-Inflammatory Pathway (CAIP).
However, its detailed mechanism and whether acupuncture at LI11 and ST25 have similar effects to ST36 remain unclear.
Aim.
To explore the effects of electroacupuncture (EA) at ST36, LI11, and ST25 on septic rats and investigate the role of the spleen in the treatment of EA at ST36.
Methods.
A septic rat model caused by cecal ligation and puncture (CLP) and a postsplenectomy (SPX) CLP rat model were established.
Rats were divided into nine groups depending on different treatments.
Serum levels of TNF-α, IL-10, D-lactic acidosis (D-LA), double amine oxidase (DAO), and T-lymphocyte subgroup level in intestinal lymph nodes were compared.
Results.
EA could not improve the 2-day survival of CLP rats.
For CLP rats, EA at ST36 and LI11 significantly decreased the levels of TNF-α, IL-10, DAO, and D-LA in serum and normalized intestinal T-cell immunity.
For SPX CLP rats, EA at ST36 failed to reduce serum concentrations of TNF-α, IL-10, and D-LA but increased the values of CD3+CD4+/CD3+CD8+ cells and Treg/Th17 cells.
Conclusions.
EA at ST36 and LI11, respectively, could alleviate inflammation reaction, protect the intestinal barrier, and maintain intestinal T-cell function in septic rats.
Spleen participated in the protective effect of EA at ST36 in sepsis.
American Psychological Association (APA)
Xie, Dong-ping& Zhou, Geng-biao& Chen, Rui-lan& Qin, Xiao-lian& Du, Jiong-dong& Zhang, Yan…[et al.]. 2020. Effect of Electroacupuncture at Zusanli (ST36) on Sepsis Induced by Cecal Ligation Puncture and Its Relevance to Spleen. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155007
Modern Language Association (MLA)
Xie, Dong-ping…[et al.]. Effect of Electroacupuncture at Zusanli (ST36) on Sepsis Induced by Cecal Ligation Puncture and Its Relevance to Spleen. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1155007
American Medical Association (AMA)
Xie, Dong-ping& Zhou, Geng-biao& Chen, Rui-lan& Qin, Xiao-lian& Du, Jiong-dong& Zhang, Yan…[et al.]. Effect of Electroacupuncture at Zusanli (ST36) on Sepsis Induced by Cecal Ligation Puncture and Its Relevance to Spleen. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155007
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155007