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The Novel Nutraceutical KJS018A Prevents Hepatocarcinogenesis Promoted by Inflammation
Joint Authors
Huynh, Do Luong
Zhang, Jiao Jiao
Kim, Nameun
Park, Yang-Ho
Kwon, Taeho
Jeong, Dong Kee
Chandimali, Nisansala
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inflammation is tightly associated with carcinogenesis at both the initiation and development of tumor.
Many reports indicated that Cox-2 substantially contributes to inflammation and tumorigenesis.
The novel nutraceutical KJS018A (BRM270 Function Enhanced Products) is the extract mixture from 8 herbal plants, which have been used to inhibit cancers and inflammation.
The aim of the present study is to examine the inhibitory effects of KJS018A mixture to hepatocarcinogenesis and inflammation.
The results showed that KJS018A significantly inhibited the proliferation of hepatic malignant cells and downregulated levels of IL-6 and Cox-2.
Furthermore, KJS018A diminished the effect of PMA, an inflammatory inducer via IL-6/STAT3/Cox-2 pathway.
Furthermore, KJS018A suppressed metastatic traits of hepatic malignant cells via downregulating Twist, N-cadherin, and MMP-9 while restoring E-cadherin expression.
KJS018A also restrained tumor growth and levels of IL-6 and Cox-2 in immunohistochemistry staining.
Taken together, these data suggest potential application of KJS018A in prevention of hepatocarcinogenesis promoted by inflammation.
American Psychological Association (APA)
Huynh, Do Luong& Chandimali, Nisansala& Zhang, Jiao Jiao& Kim, Nameun& Park, Yang-Ho& Kwon, Taeho…[et al.]. 2018. The Novel Nutraceutical KJS018A Prevents Hepatocarcinogenesis Promoted by Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155025
Modern Language Association (MLA)
Huynh, Do Luong…[et al.]. The Novel Nutraceutical KJS018A Prevents Hepatocarcinogenesis Promoted by Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1155025
American Medical Association (AMA)
Huynh, Do Luong& Chandimali, Nisansala& Zhang, Jiao Jiao& Kim, Nameun& Park, Yang-Ho& Kwon, Taeho…[et al.]. The Novel Nutraceutical KJS018A Prevents Hepatocarcinogenesis Promoted by Inflammation. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155025