Salidroside Modulates Insulin Signaling in a Rat Model of Nonalcoholic Steatohepatitis
Joint Authors
Li, Hongshan
Ying, Hao
Hu, Airong
Li, Dezhou
Hu, Yaoren
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A growing body of evidence has shown the beneficial effects of salidroside in cardiovascular and metabolic diseases.
This study aimed to evaluate the therapeutic effects of salidroside on nonalcoholic steatohepatitis (NASH) in rats and explore the underlying mechanisms related to insulin signaling.
A rat model of NASH was developed by high-fat diet for 14 weeks.
From week 9 onward, the treatment group received oral salidroside (4.33 mg/kg) daily for 6 weeks.
Salidroside effectively attenuated steatosis and vacuolation of hepatic tissue, with a dramatic decrease in liver triglycerides and free fatty acid levels (P < 0.01).
Dysregulation of FINS, FBG, HOMA-IR, ALT, and AST in serum was ameliorated with salidroside treatment (P < 0.01).
In the liver, salidroside induced significant increases in key molecules in the insulin signaling pathway, such as phosphorylated insulin receptor substrate 1 (IRS1), phosphoinositide 3-kinase (PI3K), and protein kinase B (PKB), with a significant decrease in SREBP-1c levels (P < 0.01).
Therefore, salidroside effectively protected rats from high-fat-diet-induced NASH, which may be partially attributed to its effects on the hepatic insulin signaling pathway.
American Psychological Association (APA)
Li, Hongshan& Ying, Hao& Hu, Airong& Li, Dezhou& Hu, Yaoren. 2017. Salidroside Modulates Insulin Signaling in a Rat Model of Nonalcoholic Steatohepatitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1155048
Modern Language Association (MLA)
Li, Hongshan…[et al.]. Salidroside Modulates Insulin Signaling in a Rat Model of Nonalcoholic Steatohepatitis. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1155048
American Medical Association (AMA)
Li, Hongshan& Ying, Hao& Hu, Airong& Li, Dezhou& Hu, Yaoren. Salidroside Modulates Insulin Signaling in a Rat Model of Nonalcoholic Steatohepatitis. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1155048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155048