Intestinal Schwannoma: A Clinicopathological, Immunohistochemical, and Prognostic Study of 9 Cases
Joint Authors
Shu, Zhenbo
Li, Chunsheng
Sun, Mingze
Li, Zhongmin
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Intestinal schwannoma is a type of intestinal interstitial tumor with a very low incidence.
At present, there are few studies on intestinal schwannoma.
Methods.
From January 2010 to January 2018, the patients diagnosed with intestinal schwannoma at the China-Japan Union Hospital of Jilin University were retrospectively reviewed.
The patients’ clinicopathological features and prognosis were analyzed.
Results.
This study enrolled 9 patients with intestinal schwannoma, including 3 males and 6 females.
The main symptoms of the patients were abdominal pain and melena.
Abdominal computed tomography showed intussusception, slightly high-density shadowing in the intestine, thickening of the intestinal wall, and an intestinal mass.
Colonoscopy and endoscopic ultrasonography showed submucosal masses without ulcer formation.
Two patients underwent endoscopic biopsy, and the pathological results revealed inflammation and necrosis.
One patient had increased neuron-specific enolase (NSE) levels.
Immunohistochemical analysis showed that the tumor cells were positive for S-100 and negative for CD117, DOG-1, desmin, and smooth muscle actin.
An average of 17 lymph nodes were found around the intestines in 4 patients, all of which demonstrated reactive hyperplasia.
No recurrence or metastasis occurred during postoperative follow-up.
Conclusions.
Intestinal schwannoma is a rare tumor, and in our study its incidence was higher in women than in men.
The main symptoms were abdominal pain and melena.
Preoperative increases in NSE levels might contribute to a diagnosis.
Complete surgical resection with free negative margins is the standard treatment for benign schwannoma.
There was no recurrence or metastasis after complete surgical resection, suggesting that follow-up may not be required.
American Psychological Association (APA)
Shu, Zhenbo& Li, Chunsheng& Sun, Mingze& Li, Zhongmin. 2019. Intestinal Schwannoma: A Clinicopathological, Immunohistochemical, and Prognostic Study of 9 Cases. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1155050
Modern Language Association (MLA)
Shu, Zhenbo…[et al.]. Intestinal Schwannoma: A Clinicopathological, Immunohistochemical, and Prognostic Study of 9 Cases. Gastroenterology Research and Practice No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1155050
American Medical Association (AMA)
Shu, Zhenbo& Li, Chunsheng& Sun, Mingze& Li, Zhongmin. Intestinal Schwannoma: A Clinicopathological, Immunohistochemical, and Prognostic Study of 9 Cases. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1155050
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155050