![](/images/graphics-bg.png)
Synergistic Uric Acid-Lowering Effects of the Combination of Chrysanthemum indicum Linne Flower and Cinnamomum cassia (L.) J. Persl Bark Extracts
Joint Authors
Kim, Seung-Hyung
Lee, Yun Mi
Kim, Ohn-Soon
Lee, Young-Sil
Son, Eunjung
Kim, Dong-Seon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (L.) J.
Persl bark (CB) extracts have served as the main ingredients in several prescriptions designed to treat hyperuricemia and gout in traditional Chinese and Korean medicine.
However, little is known about the combination effects of a CF and CB (CC) mixture on hyperuricemia.
In our study, we investigated the antihyperuricemic effects of CC mixture and the mechanisms underlying these effects in normal and potassium oxonate- (PO-) induced hyperuricemic rats.
The CC mixture significantly decreased uric acid levels in normal and PO-induced hyperuricemic rats and showed the enhanced hypouricemic effect compared to CF or CB alone.
Furthermore, the CC mixture increased renal uric acid excretion in PO-induced hyperuricemic rat.
We found that CC mixture and its major components, chlorogenic acid, 3,4-dicaffeoylquinic acid (isochlorogenic acid), coumarin, cinnamaldehyde, trans-cinnamic acid, and o-methoxycinnamaldehyde, inhibit the activity of xanthine oxidase (XOD) in vitro.
The CC mixture exerts antihyperuricemic effects accompanied partially by XOD activity inhibition.
Therefore, the CC mixture may have potential as a treatment for hyperuricemia and gout.
American Psychological Association (APA)
Lee, Young-Sil& Son, Eunjung& Kim, Seung-Hyung& Lee, Yun Mi& Kim, Ohn-Soon& Kim, Dong-Seon. 2017. Synergistic Uric Acid-Lowering Effects of the Combination of Chrysanthemum indicum Linne Flower and Cinnamomum cassia (L.) J. Persl Bark Extracts. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1155067
Modern Language Association (MLA)
Lee, Young-Sil…[et al.]. Synergistic Uric Acid-Lowering Effects of the Combination of Chrysanthemum indicum Linne Flower and Cinnamomum cassia (L.) J. Persl Bark Extracts. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1155067
American Medical Association (AMA)
Lee, Young-Sil& Son, Eunjung& Kim, Seung-Hyung& Lee, Yun Mi& Kim, Ohn-Soon& Kim, Dong-Seon. Synergistic Uric Acid-Lowering Effects of the Combination of Chrysanthemum indicum Linne Flower and Cinnamomum cassia (L.) J. Persl Bark Extracts. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1155067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155067