Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats
Joint Authors
Shi, Jin-Li
Zhao, Cheng-Bo-Wen
Liu, Jie
Wang, Shao-Nan
Ding, Yong-Sheng
He, Shuai
Lin, Ming-Xuan
Luo, Jing
Jiang, Yi-Nan
Bian, Li-Hua
Yao, Zi-Wei
Li, Qiu-Yu
Wang, Xiao-Mei
Guo, Jian-You
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Herb-pairs are the basic units of composition in Chinese herbal formulae, where the bridge linking Chinese medicine and prescription consists of two Chinese medicine herbs.
The Suanzaoren-Wuweizi herb-pair (SWHP) is commonly used as a sedative or tranquilizer.
SWHP has been demonstrated to exert an antianxiety effect in animal models of anxiety.
However, little information about its mechanism is available and the effects of SWHP have not been investigated.
This study examined the effects of SWHP on ameliorating anxiety-like behaviors by regulating endocannabinoids system (ECS)—brain-derived neurotrophic factor (BDNF)—extracellular regulated protein kinases (ERK) signaling pathway expression, induced by restraint stress (RS) procedures.
The antianxiety effects of SWHP on RS rats were then examined through the open-field test (OF) and the elevated plus maze test (EPM).
The concentration of BNDF, ERK1/2, p-ERK1/2, cAMP-response element binding protein (CREB), and p-CREB expression in the prefrontal cortex and hippocampus of the rats was then measured by western blot.
The number of positive cells of CB1 and CB2 in the rats’ hippocampus CA1 region was measured by immunohistochemistry.
These results gave compelling evidence that SWHP could modify anxiety-like behaviors of RS rats through regulation of the ECS-BDNF-ERK signaling pathway.
Our study demonstrated that SWHP improved anxiety-like behaviors in RS rat models by regulating the ECS-BDNF-ERK signaling pathway.
The findings indicate that SWHP may have a therapeutic application in the RS model of anxiety disorder, which proposes a potential new direction for research into anxiety disorders regarding mechanisms and the development of novel antianxiety drugs.
American Psychological Association (APA)
Zhao, Cheng-Bo-Wen& Liu, Jie& Shi, Jin-Li& Wang, Shao-Nan& Ding, Yong-Sheng& He, Shuai…[et al.]. 2020. Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1155069
Modern Language Association (MLA)
Zhao, Cheng-Bo-Wen…[et al.]. Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1155069
American Medical Association (AMA)
Zhao, Cheng-Bo-Wen& Liu, Jie& Shi, Jin-Li& Wang, Shao-Nan& Ding, Yong-Sheng& He, Shuai…[et al.]. Anxiolytic Effect of Alcohol-Water Extracted Suanzaoren-Wuweizi Herb-Pair by Regulating ECS-BDNF-ERK Signaling Pathway Expression in Acute Restraint Stress Male Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1155069
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155069