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Integrative Approach to Facilitate Fracture Healing: Topical Chinese Herbal Paste with Oral Strontium Ranelate
Joint Authors
Ko, Chun-Hay
Shum, Wai-Ting
Shiu, Hoi-Ting
Yu, Ho-Nam
Hung, Leung-Kim
Leung, Ping-Chung
Siu, Wing Sum
Lau, Clara Bik-San
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Strontium ranelate (SrR) is one of the pharmaceutical agents reported to be effective on the promotion of fracture healing.
This study aimed to evaluate the integrative effect of the oral SrR with a topical Chinese herbal paste, namely, CDR, on facilitation of bone healing.
The in vivo efficacy was evaluated using rats with tibial fracture.
They were treated with either CDR topically, or SrR orally, or their combined treatments.
The in vivo results illustrated a significant additive effect of CDR on SrR in increasing the yield load of the fractured tibia.
The in vitro results showed that neither SrR nor CDR exhibited a cytotoxic effect on UMR106 and bone-marrow stem cell (BMSC), but both of them increased the proliferation of BMSC at low concentrations.
The combination of CDR at 200 μg/mL with SrR at 200 or 400 μg/ml also showed an additive effect on increasing the ALP activity of BMSC.
Both SrR and CDR alone reduced osteoclast formation, and the effective concentration of SrR to inhibit osteoclastogenesis was reduced in the presence of CDR.
This integrative approach by combining oral SrR and topical CDR is effective in promoting fracture healing properly due to their additive effects on proosteogenic and antiosteoclastogenic properties.
American Psychological Association (APA)
Siu, Wing Sum& Shiu, Hoi-Ting& Ko, Chun-Hay& Shum, Wai-Ting& Yu, Ho-Nam& Lau, Clara Bik-San…[et al.]. 2017. Integrative Approach to Facilitate Fracture Healing: Topical Chinese Herbal Paste with Oral Strontium Ranelate. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1155077
Modern Language Association (MLA)
Siu, Wing Sum…[et al.]. Integrative Approach to Facilitate Fracture Healing: Topical Chinese Herbal Paste with Oral Strontium Ranelate. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1155077
American Medical Association (AMA)
Siu, Wing Sum& Shiu, Hoi-Ting& Ko, Chun-Hay& Shum, Wai-Ting& Yu, Ho-Nam& Lau, Clara Bik-San…[et al.]. Integrative Approach to Facilitate Fracture Healing: Topical Chinese Herbal Paste with Oral Strontium Ranelate. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1155077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155077