Grain Amaranth Is Associated with Improved Hepatic and Renal Calcium Metabolism in Type 2 Diabetes Mellitus of Male Wistar Rats
Joint Authors
Safiriyu, Abass Alao
Kasozi, Keneth Iceland
Namubiru, Sarah
Ninsiima, Herbert Izo
Nakimbugwe, Dorothy
Namayanja, Monica
Valladares, Miriela Betancourt
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Dysregulation of calcium signaling is a hallmark of diabetes mellitus (DM) and grain amaranth (AG) has antidiabetic properties.
Information on the mechanism of action of AG on blood, renal, and hepatic tissues is sparse, although it continues to be an important alternative medicinal plant in several developing countries.
The objective of the study was to determine key changes in calcium levels and s100a1 protein levels and antioxidant and histopathologic changes in blood, renal, and hepatic tissues of male diabetic Wistar rats.
Materials and Methods.
This was an experimental study in which 30 male Wistar rats were kept for 5 weeks (6 groups, N =5).
Groups 1-IV had T2DM induced using Nicotinamide and Streptozotocin: Group I, Mixtard®; group II, positive control; group III, 25% AG; group IV, 50% AG.
Furthermore, group V consisted of normal rats given 50% GA and group VI was negative control.
Blood, renal, and hepatic tissues were collected and analyzed for calcium, s100a1 protein levels, and antioxidant and histopathological changes.
Results and Discussion.
In blood, renal, and hepatic tissue, calcium and s100a1 levels were low during T2DM and these increased following AG supplementation.
This was important for improved metabolic processes, thus leading to the low malondialdehyde (MDA) and glutathione peroxidase (GPx) activity in the tissues.
Efficient antioxidant status was important for improved calcium signaling mechanisms, thus leading to improved tissue function and protection demonstrating the importance of AG as an alternative medicinal source through the calcium signaling pathway.
Conclusion.
Grain amaranth exerts its antidiabetic properties through improved calcium homeostasis in blood, kidney, and liver.
American Psychological Association (APA)
Kasozi, Keneth Iceland& Namubiru, Sarah& Safiriyu, Abass Alao& Ninsiima, Herbert Izo& Nakimbugwe, Dorothy& Namayanja, Monica…[et al.]. 2018. Grain Amaranth Is Associated with Improved Hepatic and Renal Calcium Metabolism in Type 2 Diabetes Mellitus of Male Wistar Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155081
Modern Language Association (MLA)
Kasozi, Keneth Iceland…[et al.]. Grain Amaranth Is Associated with Improved Hepatic and Renal Calcium Metabolism in Type 2 Diabetes Mellitus of Male Wistar Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1155081
American Medical Association (AMA)
Kasozi, Keneth Iceland& Namubiru, Sarah& Safiriyu, Abass Alao& Ninsiima, Herbert Izo& Nakimbugwe, Dorothy& Namayanja, Monica…[et al.]. Grain Amaranth Is Associated with Improved Hepatic and Renal Calcium Metabolism in Type 2 Diabetes Mellitus of Male Wistar Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155081