Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis
Joint Authors
Kim, John J.
Du, Lijun
Chen, Binrui
Zhang, Yawen
Ren, Hui
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Functional dyspepsia (FD) is a common chronic gastrointestinal disorder with a complex, undefined mechanism.
Clustering of patients with FD in families highlights the role of genetic factors in the pathogenesis of FD.
We performed a systematic review and meta-analysis to clarify the associations between specific gene polymorphisms and FD susceptibility.
PubMed, EMBASE, the Cochrane Library, and HuGE database were searched.
An additive model was adopted to determine whether previous studied genes are associated with FD susceptibility.
Carriers of minor allele in GNB3 825C>T (OR=1.15, 95% CI 0.99-1.34, P=0.07), SCL6A4 5HTTLPR (OR=0.92, 95% CI 0.75-1.12, P=0.40), and CCK-1R 779T>C (OR=0.86, 95% CI 0.72-1.03, P=0.09) genes failed to demonstrate susceptibility to FD.
In a subgroup analysis, only minor allele (T) in GNB3 825C>T was associated with an increased susceptibility to the epigastric pain syndrome subtype (OR=1.34, 95% CI 1.10-1.63, P=0.003).
Our meta-analysis based on available studies using an additive model failed to show that GNB3, SCL6A4, and CCK-1R polymorphisms are associated with FD susceptibility.
American Psychological Association (APA)
Du, Lijun& Kim, John J.& Chen, Binrui& Zhang, Yawen& Ren, Hui. 2019. Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1155082
Modern Language Association (MLA)
Du, Lijun…[et al.]. Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1155082
American Medical Association (AMA)
Du, Lijun& Kim, John J.& Chen, Binrui& Zhang, Yawen& Ren, Hui. Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1155082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155082