Protective Effects of Biscoclaurine Alkaloids on Leukopenia Induced by 60Co-γ Radiation
Joint Authors
Sun, Xiao-Bo
Sun, Gui-Bo
Xu, Xudong
Xie, Xueheng
Du, Yuyang
Ma, Guoxu
Wang, Min
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
Leukopenia, a common complication of tumor chemoradiotherapy, contributes serious damage to the hematopoietic, gastrointestinal, and immune systems of the body and can cause delay, discontinuation, or even failure to tumor treatment, thereby greatly threatening human health.
The present study aims to investigate the protective effects of biscoclaurine alkaloids (BA) on leukopenia.
Methods.
This study was conducted on 60 Kunming mice, which were randomly divided into six groups containing 10 animals each.
A hematology analyzer was used to count white blood cells (WBC) in the peripheral blood cell.
Mice serum was collected, and the granulocyte-macrophage colony-stimulating factor, vascular cell adhesion molecule 1 (VCAM-1), and interferon-γ (IFN-γ) were detected by enzyme-linked immunosorbent assays.
Pathological changes were detected through hematoxylin and eosin staining in the liver and spleen of mice.
The spleen and liver ultrastructures were observed via electron microscopy.
Results.
Results showed that BA ameliorated WBC, PLT reduction in the peripheral blood and significantly increased the levels of IFN-γ and VCAM-1 in mice serum.
BA reduced ionizing radiation-induced injuries to spleen, mitigated the reduction of superoxide dismutase (SOD), and significantly decreased the malonaldehyde (MDA) and xanthine oxidase (XOD) levels in the liver.
Conclusion.
BA enhanced the immune and hematopoietic functions and ameliorated the oxidative stress induced by 60Co-γ radiation, revealing its therapeutic potential both as a radioprotector and as a radiation mitigator for leukopenia induced by 60Co-γ radiation.
American Psychological Association (APA)
Wang, Min& Xie, Xueheng& Du, Yuyang& Ma, Guoxu& Xu, Xudong& Sun, Gui-Bo…[et al.]. 2020. Protective Effects of Biscoclaurine Alkaloids on Leukopenia Induced by 60Co-γ Radiation. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155097
Modern Language Association (MLA)
Wang, Min…[et al.]. Protective Effects of Biscoclaurine Alkaloids on Leukopenia Induced by 60Co-γ Radiation. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1155097
American Medical Association (AMA)
Wang, Min& Xie, Xueheng& Du, Yuyang& Ma, Guoxu& Xu, Xudong& Sun, Gui-Bo…[et al.]. Protective Effects of Biscoclaurine Alkaloids on Leukopenia Induced by 60Co-γ Radiation. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155097