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Antimalarial Activity of Stem Bark of Periploca linearifolia during Early and Established Plasmodium Infection in Mice
Joint Authors
Endale Gurmu, Abyot
Wubneh, Zewdu Birhanu
Belay, Wubetu Yihunie
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
In Ethiopia, stem bark of Periploca linearifolia is used for the treatment of malaria by the local community and demonstrated antimalarial activity in vitro.
Despite its in vitro antimalarial activity, no scientific study has been carried out to verify its activity in vivo.
Therefore, the aim of the study was to evaluate the antimalarial activity of Periploca linearifolia stem bark extract in mice.
Methods.
The dried stem bark of Periploca linearifolia was extracted with 80% methanol and evaluated for its antimalarial activity on both early and established Plasmodium berghei infected mice.
The extract was prepared at graded doses of 200, 400, and 600 mg/kg.
Chloroquine and distilled water were administered to the positive and negative control groups, respectively.
Results.
The crude extract, at all tested doses, suppressed parasitemia significantly (p<0.05) for 200 and 400 mg/kg and (p<0.001) for 600 mg/kg.
The suppression values at these doses were 56.98, 43.33, and 38.17 percent, respectively.
Periploca linearifolia extract also demonstrated schizonticidal activity in the established malaria infection.
Conclusion.
The plant Periploca linearifolia has a promising antimalarial activity in mice, supporting its in vitro finding.
Thus, it could be considered as a potential source to develop new antimalarial agent.
American Psychological Association (APA)
Belay, Wubetu Yihunie& Endale Gurmu, Abyot& Wubneh, Zewdu Birhanu. 2018. Antimalarial Activity of Stem Bark of Periploca linearifolia during Early and Established Plasmodium Infection in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1155102
Modern Language Association (MLA)
Belay, Wubetu Yihunie…[et al.]. Antimalarial Activity of Stem Bark of Periploca linearifolia during Early and Established Plasmodium Infection in Mice. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1155102
American Medical Association (AMA)
Belay, Wubetu Yihunie& Endale Gurmu, Abyot& Wubneh, Zewdu Birhanu. Antimalarial Activity of Stem Bark of Periploca linearifolia during Early and Established Plasmodium Infection in Mice. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1155102
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155102