Xiaoyukang Jiaonang Promotes the Degradation of Hypoxia-Inducible Factor 1α and Antiangiogenesis and Anti-Inflammation in Chronic Subdural Hematoma Rat Model
Joint Authors
Li, Zhonghao
Dong, Xiaoke
Liu, Jinmin
Liu, Chongchong
Liu, Jialin
Wang, Gesheng
Zhou, Yujia
Wang, Kaiyue
Li, Lili
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Xiaoyukang Jiaonang (XYK) is a Chinese patent medicine approved by the National Medical Product Administration which is used to treat intracranial hematoma in China.
In this study, we observed the molecular mechanism of XYK in hypoxia-inducible factor 1α (HIF-1α), inflammation and angiogenesis of chronic subdural hematoma (CSDH).
The CSDH model was made by using internal iliac vein blood of Wister rats, and rats were divided into sham group, CSDH group and XYK group.
The rats in the XYK group were gavaged with Xiaoyukang Jiaonang (185 mg/kg) for 7 days, and rats in the CSDH group and sham group were gavaged with the same amount of physiological saline for 7 days.
In the CSHD rat model, active inflammation and angiogenesis were observed around the hematoma.
XYK promoted the ubiquitination and degradation of HIF-1α, and reduced the concentration of VEGF and the ratio of angiopoietin-1/angiopoietin-2.
XYK reduced proinflammatory cytokines and increased anti-inflammatory cytokine.
In tissue section, XYK reduced the size of the hematoma and membrane, and reduced vWF positive cells in membrane.
Furthermore, the endothelial progenitor cells in blood decreased as well.
Overall, XYK shows anti-inflammatory and antiangiogenesis effects which may relate to the degradation of HIF-1α.
American Psychological Association (APA)
Liu, Jialin& Dong, Xiaoke& Li, Zhonghao& Wang, Gesheng& Zhou, Yujia& Liu, Chongchong…[et al.]. 2020. Xiaoyukang Jiaonang Promotes the Degradation of Hypoxia-Inducible Factor 1α and Antiangiogenesis and Anti-Inflammation in Chronic Subdural Hematoma Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1155116
Modern Language Association (MLA)
Liu, Jialin…[et al.]. Xiaoyukang Jiaonang Promotes the Degradation of Hypoxia-Inducible Factor 1α and Antiangiogenesis and Anti-Inflammation in Chronic Subdural Hematoma Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1155116
American Medical Association (AMA)
Liu, Jialin& Dong, Xiaoke& Li, Zhonghao& Wang, Gesheng& Zhou, Yujia& Liu, Chongchong…[et al.]. Xiaoyukang Jiaonang Promotes the Degradation of Hypoxia-Inducible Factor 1α and Antiangiogenesis and Anti-Inflammation in Chronic Subdural Hematoma Rat Model. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1155116
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155116