Renoprotective Effect of Yiqi Yangyin Huayu Tongluo Formula against Diabetic Nephropathy in Diabetic Rats
Joint Authors
Han, Lin
Qin, Jian-guo
Wang, Feng-li
Wang, Yue-hua
An, Hai-yan
Zhang, Jiang-hua
Zhang, Xue-yun
Chen, Zhi-qiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic nephropathy is developed in 20-40% of patients with diabetes mellitus, and patients with diabetic nephropathy require dialysis and renal transplantation.
Traditional Chinese medicine has been widely used in treating patients with diabetic nephropathy in China.
However, the detailed mechanisms of traditional Chinese medicine remain unclear.
Yiqi Yangyin Huayu Tongluo formula (ZY formula) is a traditional Chinese medicinal formula.
Here, we demonstrated kidney protective effect of ZY formula on the rats with diabetic nephropathy.
The therapeutic effect of ZY formula on the diabetic nephropathy was almost the same as that of Irbesartan, which proved to have excellent curative effects on diabetic nephropathy.
We also demonstrated the mechanism of ZY formula effect on the diabetic nephropathy.
First, we validated that the activation of ROS-JNK signaling pathway in diabetic rats could be reduced by ZY.
Furthermore, collagen I expression could be downregulated by ZY formula treatment.
Meanwhile, cell apoptosis in the kidney of diabetic rats could be alleviated by ZY formula.
American Psychological Association (APA)
Wang, Feng-li& Wang, Yue-hua& Han, Lin& An, Hai-yan& Zhang, Jiang-hua& Zhang, Xue-yun…[et al.]. 2018. Renoprotective Effect of Yiqi Yangyin Huayu Tongluo Formula against Diabetic Nephropathy in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155139
Modern Language Association (MLA)
Wang, Feng-li…[et al.]. Renoprotective Effect of Yiqi Yangyin Huayu Tongluo Formula against Diabetic Nephropathy in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1155139
American Medical Association (AMA)
Wang, Feng-li& Wang, Yue-hua& Han, Lin& An, Hai-yan& Zhang, Jiang-hua& Zhang, Xue-yun…[et al.]. Renoprotective Effect of Yiqi Yangyin Huayu Tongluo Formula against Diabetic Nephropathy in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155139
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155139