Zuo Jin Wan Reverses DDP Resistance in Gastric Cancer through ROCKPTENPI3K Signaling Pathway
Joint Authors
Tang, Qing-Feng
Sun, Jian
Tao, Jie
Sun, Meng-Yao
Yuan, Yu-Xia
Ni, Zhen-Hua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Gastric cancer (GC) is the third leading cause of cancer-related death.
Chemotherapy resistance remains the major reason for GC treatment failure and poor overall survival of patients.
Our previous studies have proved that Zuo Jin Wan (ZJW), a traditional Chinese medicine (TCM) formula, could significantly enhance the sensitivity of cisplatin (DDP)-resistant gastric cancer cells to DDP by inducing apoptosis via mitochondrial translocation of cofilin-1.
However, the underlying mechanism remains poorly understood.
This study aimed to evaluate the effects of ROCK/PTEN/PI3K on ZJW-induced apoptosis in vitro and in vivo.
We found that ZJW could significantly activate the ROCK/PTEN pathway, inhibit PI3K/Akt, and promote the apoptosis of SGC-7901/DDP cells.
Inhibition of ROCK obviously attenuated ZJW-induced apoptosis as well as cofilin-1 mitochondrial translocation, while inhibition of PI3K had the opposite effects.
In vivo, combination treatment of DDP and ZJW (2000 mg/kg) significantly reduced tumor growth compared with DDP alone.
Moreover, the combined administration of ZJW and DDP increased the expression of cleaved ROCK and p-PTEN while it decreased p-PI3K and p-cofilin-1, which was consistent with our in vitro results.
These findings indicated that ZJW could effectively inhibit DDP resistance in GC by regulating ROCK/PTEN/PI3K signaling and provide a promising treatment strategy for gastric cancer.
American Psychological Association (APA)
Sun, Meng-Yao& Sun, Jian& Tao, Jie& Yuan, Yu-Xia& Ni, Zhen-Hua& Tang, Qing-Feng. 2018. Zuo Jin Wan Reverses DDP Resistance in Gastric Cancer through ROCKPTENPI3K Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155143
Modern Language Association (MLA)
Sun, Meng-Yao…[et al.]. Zuo Jin Wan Reverses DDP Resistance in Gastric Cancer through ROCKPTENPI3K Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1155143
American Medical Association (AMA)
Sun, Meng-Yao& Sun, Jian& Tao, Jie& Yuan, Yu-Xia& Ni, Zhen-Hua& Tang, Qing-Feng. Zuo Jin Wan Reverses DDP Resistance in Gastric Cancer through ROCKPTENPI3K Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155143