Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of Helicobacter pylori
Joint Authors
Wang, Yongjun
Zhu, Shengtao
Zhang, Shutian
Guo, Shuilong
Li, Lei
Meng, FanDong
Zhao, Xin
Sun, YiLin
Zhang, Yan
Wang, QinQin
Xu, HuFeng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Bismuth-containing quadruple therapy has been recommended as the first line of treatment in areas of high clarithromycin or metronidazole resistance.
However, safety concerns of bismuth agents have long been raised.
We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth compounds consisting of three synthetic drugs and five medicinal herbs, compared to bismuth aluminate and colloidal bismuth subcitrate (CBS) in H.
pylori-infected mouse model.
We then used atomic fluorescence spectroscopy and autometallography to measure the accumulation of three bismuth agents in the brain, heart, liver, and kidneys in adult Sprague-Dawley rats.
We also evaluated the safety of bismuth agents by conducting clinical biochemistry tests in blood samples of experimental animals.
Wei Bi Mei granules exhibited the highest efficacy of anti-H.
pylori activity and yielded the lowest bismuth accumulation when compared to CBS and bismuth aluminate.
Our findings show that Wei Bi Mei granules are a safe Chinese medicinal herb with potent anti-H.
pylori activity and can be considered as an alternative to current bismuth compounds.
Thus, Wei Bi Mei granules merit further evaluation, particularly with regard to efficacy and safety when they are combined with other H.
pylori eradication medications in the clinical setting.
American Psychological Association (APA)
Li, Lei& Meng, FanDong& Zhu, Shengtao& Guo, Shuilong& Wang, Yongjun& Zhao, Xin…[et al.]. 2018. Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of Helicobacter pylori. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155153
Modern Language Association (MLA)
Li, Lei…[et al.]. Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of Helicobacter pylori. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1155153
American Medical Association (AMA)
Li, Lei& Meng, FanDong& Zhu, Shengtao& Guo, Shuilong& Wang, Yongjun& Zhao, Xin…[et al.]. Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of Helicobacter pylori. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155153