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Hypoglycaemic and Antioxidant Effects of Propolis of Chihuahua in a Model of Experimental Diabetes
Joint Authors
Ibarra-Barajas, Maximiliano
Rodriguez-Canales, Mario
Canales-Martinez, Maria Margarita
Rivera-Yañez, Nelly
Nieto-Yañez, Oscar
Rodriguez-Monroy, Marco Aurelio
Jimenez-Estrada, Manuel
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Propolis is a bee-collected natural product that has been proven to have various bioactivities.
This study tested the effects of a Mexican propolis on streptozotocin-induced diabetes mellitus in a murine model.
The results showed that an ethanolic extract of propolis of Chihuahua (EEPCh) significantly inhibited increases in blood glucose and the loss of body weight in diabetic mice.
EEPCh increased plasma insulin levels in STZ-diabetic mice, whereas, in untreated diabetic mice, there was no detection of insulin.
EEPCh had a high antioxidant capacity (SA50 = 15.75 μg/mL), which was directly related to the concentrations of total phenols (314 mg GAE/g of extract) and flavonoids (6.25 mg QE/g of extract).
In addition, increased activities of the enzymes superoxide dismutase, catalase, and glutathione peroxidase were observed in diabetic mice treated with EEPCh.
Compounds such as pinocembrin, quercetin, naringin, naringenin, kaempferol, acacetin, luteolin, and chrysin were identified by HPLC-MS analysis.
This investigation demonstrated that propolis of Chihuahua possesses hypoglycaemic and antioxidant activities and can alleviate symptoms of diabetes mellitus in mice.
These effects may be directly related to the chemical composition of propolis, as most of the compounds identified in propolis are reportedly active in terms of the different parameters evaluated in this work.
American Psychological Association (APA)
Rivera-Yañez, Nelly& Rodriguez-Canales, Mario& Nieto-Yañez, Oscar& Jimenez-Estrada, Manuel& Ibarra-Barajas, Maximiliano& Canales-Martinez, Maria Margarita…[et al.]. 2018. Hypoglycaemic and Antioxidant Effects of Propolis of Chihuahua in a Model of Experimental Diabetes. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155167
Modern Language Association (MLA)
Rivera-Yañez, Nelly…[et al.]. Hypoglycaemic and Antioxidant Effects of Propolis of Chihuahua in a Model of Experimental Diabetes. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1155167
American Medical Association (AMA)
Rivera-Yañez, Nelly& Rodriguez-Canales, Mario& Nieto-Yañez, Oscar& Jimenez-Estrada, Manuel& Ibarra-Barajas, Maximiliano& Canales-Martinez, Maria Margarita…[et al.]. Hypoglycaemic and Antioxidant Effects of Propolis of Chihuahua in a Model of Experimental Diabetes. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155167