Dose Correlation of Danggui and Chuanxiong Drug Pairs in the Chinese Medicine Prescription Based on the Copula Function

Joint Authors

Fu, Chaomei
Zhao, Xuan
Lin, Wei
Li, Jiawei
Chen, Yunhui
Patel, Anamica
Zhao, Hailiang
Han, Guoxin
Hao, Yiwen
Huang, Zejuan
Zheng, Mingyue
Hu, Peng

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-11-21

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Dosage is essential for studying the compatibility and effectiveness of traditional Chinese medicine.

Danggui and Chuanxiong are widely used in traditional Chinese medicine for ailments and treatment of various disorders.

628 traditional Chinese medicine prescriptions containing Danggui and Chuanxiong were extracted from the self-built prescription database and screened for the three groups of prescriptions, i.e., irregular menstruation, sores, and stroke.

We processed and tested the dosage of Danggui and Chuanxiong and selected the optimal copula function, Gumbel copula function, from the Archimedes function family and elliptical copula function family to establish the data model.

To establish the presence of a correlation between the dose of Danggui and Chuanxiong, a graph of the joint distribution function of rank correlation coefficients, Kendall’s rank correlation coefficient and Spearman’s rank correlation coefficient, was used.

Our results suggest that the model using the Gumbel copula function better reflects the correlation between the dose of Danggui and Chuanxiong.

For irregular menstruation, sores, and strokes, Kendall’s rank correlation coefficients were 0.6724, 0.5930, and 0.7757, respectively, and Spearman’s correlation coefficients were 0.8536, 0.7812, and 0.9285, respectively.

In all three prescription groups, the dose of Danggui and Chuanxiong was positively correlated, implying that, as the dosage of one drug increases, the dosage of the other increases as well.

From the perspective of data mining and mathematical statistics, the use of the copula function model to evaluate the correlation between the prescribed dosage of the two drugs was innovative and provided a new model for the scientific interpretation of the compatibility of traditional drugs.

This might also serve to guide the clinical use of traditional Chinese medicine.

American Psychological Association (APA)

Zhao, Xuan& Lin, Wei& Li, Jiawei& Chen, Yunhui& Patel, Anamica& Zhao, Hailiang…[et al.]. 2020. Dose Correlation of Danggui and Chuanxiong Drug Pairs in the Chinese Medicine Prescription Based on the Copula Function. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155169

Modern Language Association (MLA)

Zhao, Xuan…[et al.]. Dose Correlation of Danggui and Chuanxiong Drug Pairs in the Chinese Medicine Prescription Based on the Copula Function. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1155169

American Medical Association (AMA)

Zhao, Xuan& Lin, Wei& Li, Jiawei& Chen, Yunhui& Patel, Anamica& Zhao, Hailiang…[et al.]. Dose Correlation of Danggui and Chuanxiong Drug Pairs in the Chinese Medicine Prescription Based on the Copula Function. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155169

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1155169