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Efficacy and Safety of Modified Duhuo Jisheng Decoction in the Treatment of Lumbar Disc Herniation: A Systematic Review and Meta-Analysis
Joint Authors
Tan, Mingsheng
Xiong, Zhencheng
Yi, Ping
Zhang, Liubo
Ma, Haoning
Li, Wenhao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
Lumbar disc herniation (LDH) is based on the degenerative changes of the intervertebral disc.
Many drugs are used to treat and prevent LDH, including Western medicine and Chinese medicine.
Duhuo Jisheng Decoction (DHJSD) is one of the most classic Chinese medicine prescriptions.
The purpose of our meta-analysis is to evaluate the efficacy and safety of modified DHJSD in the treatment of LDH.
Methods.
We searched multiple databases including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI) databases, Wanfang Database, and Chinese Scientific Journal Database (VIP) to identify studies that met the inclusion criteria.
This meta-analysis was registered at INPLASY with reference number ID: INPLASY202060053.
Results.
Fourteen randomized controlled trials (RCTs) were identified, including 1560 patients.
This meta-analysis showed that the total effective rate and cure rate of modified DHJSD are higher than those of diclofenac sodium enteric-coated tablets (total effective rate: RR = 1.18, 95% CI: 1.12 to 1.25, P<0.0001, I2 = 0%; cure rate: RR = 1.60, 95% CI: 1.30 to 1.97, P<0.00001, I2 = 2%), diclofenac sodium enteric-coated tablets plus ibuprofen and indomethacin (total effective rate: RR = 1.23, 95% CI: 1.11 to 1.37, P=0.0001, I2 = 0%; cure rate: RR = 1.58, 95% CI: 1.22 to 2.04, P=0.0005, I2 = 0%), and diclofenac sodium sustained-release capsule (total effective rate: RR = 1.49, 95% CI: 1.27 to 1.74, P<0.00001, I2 = 0%; cure rate: RR = 10.07, 95% CI: 3.29 to 30.88, P<0.00001, I2 = 5%).
Modified DHJSD was also better than Western medicine (MD = −1.56, 95% CI: −2.42 to −0.70, P=0.0004, I2 = 74%) in terms of visual analogue scale (VAS) scores.
Three RCTs showed no adverse events in the modified DHJSD group, but adverse events existed in the Western medicine group.
Conclusion.
This meta-analysis showed that modified DHJSD had a more favorable effect on the treatment of LDH than Western medicine, and there were no obvious adverse events.
More high-quality RCTs are needed to complement existing conclusions.
American Psychological Association (APA)
Xiong, Zhencheng& Yi, Ping& Zhang, Liubo& Ma, Haoning& Li, Wenhao& Tan, Mingsheng. 2020. Efficacy and Safety of Modified Duhuo Jisheng Decoction in the Treatment of Lumbar Disc Herniation: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155175
Modern Language Association (MLA)
Xiong, Zhencheng…[et al.]. Efficacy and Safety of Modified Duhuo Jisheng Decoction in the Treatment of Lumbar Disc Herniation: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1155175
American Medical Association (AMA)
Xiong, Zhencheng& Yi, Ping& Zhang, Liubo& Ma, Haoning& Li, Wenhao& Tan, Mingsheng. Efficacy and Safety of Modified Duhuo Jisheng Decoction in the Treatment of Lumbar Disc Herniation: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155175
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155175