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UPLC-QTOFMS-Based Lipidomic Profiling of Liver Qi-Stagnation and Spleen-Deficiency Syndrome in Patients with Hyperlipidemia
Joint Authors
Guo, Jiao
Shenghua, Piao
Shuyu, Tan
Kunping, Li
Huixia, Zhan
Xue, Xiao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Hyperlipidemia is a common disease caused by abnormal plasma lipid metabolism.
Lipidomics is a powerful and efficient technology to study the integration of disease and syndrome of Chinese medicine.
This study investigated specific changes in lipid metabolites from hyperlipidemia patients with syndrome of liver qi-stagnation and spleen-deficiency (SLQSD).
Lipid profiles in plasma samples from 29 hyperlipidemia patients including 10 SLQSD and 19 non-SLQSD and 26 healthy volunteers (NC) were tested by UPLC-QTOF/MS.
PLS-DA analysis and database searching were performed to discover differentiating metabolites.
Differences in lipid metabolites between hyperlipidemia and healthy people mainly include phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, and ceramides.
Hyperlipidemia patients with SLQSD and non-SLQSD could be differentiated by using identified lipid metabolites including phosphatidylcholines, phosphatidylethanolamines, phosphatidylinositols, triglycerides, diacylglycerols, lysophosphatidylethanolamines, sphingomyelins, lysophosphatidylcholines, and lactosylceramides.
There were significant differences of lipid metabolism between between different syndromes of the same disease such as hyperlipidemia which showed significant differences between SLQSD and non-SLQSD.
American Psychological Association (APA)
Shenghua, Piao& Shuyu, Tan& Kunping, Li& Huixia, Zhan& Xue, Xiao& Guo, Jiao. 2018. UPLC-QTOFMS-Based Lipidomic Profiling of Liver Qi-Stagnation and Spleen-Deficiency Syndrome in Patients with Hyperlipidemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1155224
Modern Language Association (MLA)
Shenghua, Piao…[et al.]. UPLC-QTOFMS-Based Lipidomic Profiling of Liver Qi-Stagnation and Spleen-Deficiency Syndrome in Patients with Hyperlipidemia. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1155224
American Medical Association (AMA)
Shenghua, Piao& Shuyu, Tan& Kunping, Li& Huixia, Zhan& Xue, Xiao& Guo, Jiao. UPLC-QTOFMS-Based Lipidomic Profiling of Liver Qi-Stagnation and Spleen-Deficiency Syndrome in Patients with Hyperlipidemia. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1155224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155224