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Promotion of Keratinocyte Proliferation by Tracheloside through ERK12 Stimulation
Joint Authors
Kim, Ki-Young
Kim, JaeGoo
Shin, Yu-Kyong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Cell migration and proliferation are important for proper wound healing after skin injury.
Recent studies have shown that compounds from plants could promote cell migration and proliferation.
Tracheloside, which is a plant lignan, has been found to promote the growth of HaCaT cells over 40% compared to other compounds tested based on a cell proliferation assay.
An in vitro scratch assay confirmed the healing activity of tracheloside (more than 2-fold increased healing activity after 24 hours of treatment compared with the control) and revealed that this activity is better than that of allantoin (1.2-fold increased after 24 hours of treatment compared with the control), a positive control.
With western blot results, wound healing with tracheloside occurred through the phosphorylation of ERK1/2.
Therefore, tracheloside is a good candidate to promote wound healing and could be developed as a therapeutic agent for wound treatment or used as a leading compound with higher activity.
American Psychological Association (APA)
Kim, JaeGoo& Shin, Yu-Kyong& Kim, Ki-Young. 2018. Promotion of Keratinocyte Proliferation by Tracheloside through ERK12 Stimulation. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1155239
Modern Language Association (MLA)
Kim, JaeGoo…[et al.]. Promotion of Keratinocyte Proliferation by Tracheloside through ERK12 Stimulation. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1155239
American Medical Association (AMA)
Kim, JaeGoo& Shin, Yu-Kyong& Kim, Ki-Young. Promotion of Keratinocyte Proliferation by Tracheloside through ERK12 Stimulation. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1155239
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155239