Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis
Joint Authors
Chen, Tuo
He, Zongqi
Zhou, Qing
Wu, Bensheng
Chen, Yugen
Shen, Zhao-Feng
Xu, Cheng-biao
Shang, Hong-tao
Xie, Chao-fan
Huang, Si-yi
Chen, Hai-bo
Han, Shu-tang
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Ulcerative colitis (UC) patients have an increased risk for the development of colorectal cancer (CRC).
Our aim was to assess the risk of CRC in UC patients compared with disease extent, disease duration, and geographic variation.
Methods.
In this systematic review and meta-analysis, we searched PubMed, scientific meetings, and the bibliographies of identified articles, with English language restrictions for studies published from 1988 to 2018, and assessed the risk of CRC in UC patients.
Patients with Crohn’s disease, family history of CRC, and colorectal adenomatous polyp (CAP) were excluded from this research.
The study was registered with PROSPERO, number CRD42018102213.
Findings.
We included 58 studies that included 267566 UC patients.
Extensive UC and left-sided UC had a higher risk of CRC than proctitis UC.
Geography also played a role in UC-associated CRC development.
The time of malignant transformation in Asian UC patients started after 10-20 years of this disease duration.
North American UC-associated CRC patients significantly increased in more than 30 years of this disease duration.
Conclusion.
In a systematic review of the literature, we found that disease extent, disease duration, and geography were strong, independent risk factors in UC-associated CRC development.
American Psychological Association (APA)
Zhou, Qing& Shen, Zhao-Feng& Wu, Bensheng& Xu, Cheng-biao& He, Zongqi& Chen, Tuo…[et al.]. 2019. Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1155246
Modern Language Association (MLA)
Zhou, Qing…[et al.]. Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1155246
American Medical Association (AMA)
Zhou, Qing& Shen, Zhao-Feng& Wu, Bensheng& Xu, Cheng-biao& He, Zongqi& Chen, Tuo…[et al.]. Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1155246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155246