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Antiproliferative Effects of Alkaloids from the Bulbs of Crinum abyscinicum Hochst. ExA. Rich
Joint Authors
Hymete, Ariaya
Abebe, Besufekad
Tadesse, Solomon
Bisrat, Daniel
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Crinum abyscinicum Hochst.
ExA.
Rich bulb is traditionally used in Ethiopia for the treatment of various ailments including internal parasites, mastitis, rabies, colic diseases of animals, and cancer.
Despite its importance in traditional cancer treatment, no research work has been reported on the antiproliferative activity of the bulb extract and its major constituents.
Phytochemical investigation of the bulb extract of C.
abyscinicum by PTLC over silica gel resulted in the isolation of two alkaloids, which were unequivocally identified as 6-hydroxycrinamine and lycorine on the basis of 1H- and 13C-NMR and MS analysis.
The bulb extract, 6-hydroxycrinamine, and lycorine possessed significant antiproliferative activity, lycorine being the most active exhibiting GI50 values of 2.8 μg/ml and 3.4 μg/ml against A2780 and MV4-11 cells, respectively.
Cell cycle analysis and annexin V/propidium iodide double staining in A2780 cells revealed that both compounds increased the percentage of cells in the S-phase at 30 μg/ml without inducing apoptosis.
Our results suggest that the antiproliferative activities of the bulb extract of C.
abyscinicum, 6-hydroxycrinamine, and lycorine could support the traditional claim of the plant against cancer.
American Psychological Association (APA)
Abebe, Besufekad& Tadesse, Solomon& Hymete, Ariaya& Bisrat, Daniel. 2020. Antiproliferative Effects of Alkaloids from the Bulbs of Crinum abyscinicum Hochst. ExA. Rich. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155250
Modern Language Association (MLA)
Abebe, Besufekad…[et al.]. Antiproliferative Effects of Alkaloids from the Bulbs of Crinum abyscinicum Hochst. ExA. Rich. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1155250
American Medical Association (AMA)
Abebe, Besufekad& Tadesse, Solomon& Hymete, Ariaya& Bisrat, Daniel. Antiproliferative Effects of Alkaloids from the Bulbs of Crinum abyscinicum Hochst. ExA. Rich. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155250