The Effect of Splenectomy on the Reversal of Cirrhosis: a Prospective Study
Joint Authors
Lu, Shi-Chun
Zeng, Dao-Bing
Lin, Dong-Dong
Di, Liang
Zhang, Rui-Chi
Guo, Qing-Liang
Duan, Bin-Wei
Jia, Cui-Yu
Chen, Feng
Zang, Yun-jin
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Studies have demonstrated that liver fibrosis can be reversed by medication treatments.
After splenectomy, cirrhosis patients have short-term changes in several serum markers for cirrhosis and liver stiffness.
Aims.
To investigate the effect of splenectomy on the severity of cirrhosis.
Methods.
A total of 62 patients with cirrhosis and portal hypertension receiving splenectomy from December 2014 to July 2017 were enrolled.
The degree of cirrhosis was preoperatively and postoperatively evaluated by serum markers, including hyaluronan (HA), laminin, amino-terminal propeptide of type III procollagen (PIIINP), type IV collagen (C-IV), liver stiffness (FibroScan), and liver volume.
Results.
HA levels significantly increased at 1 week and 1 month postoperation (both P<0.05), whereas the levels of PIIINP and C-IV significantly decreased from 1 month to 12 months postoperation (all P<0.05).
In addition, elastography examination demonstrated that the FibroScan score significantly reduced from 1 month to 24 months postoperation as compared with the baseline level (all P<0.05).
CT scan showed that the liver volume significantly increased at 6 months postoperation (P<0.05).
Furthermore, the alteration trends of these serum markers and the FibroScan score were further confirmed by the multivariate linear regression.
Conclusions.
These observations suggested that splenectomy may result in long-term reversal of cirrhosis.
American Psychological Association (APA)
Zeng, Dao-Bing& Di, Liang& Zhang, Rui-Chi& Guo, Qing-Liang& Duan, Bin-Wei& Jia, Cui-Yu…[et al.]. 2019. The Effect of Splenectomy on the Reversal of Cirrhosis: a Prospective Study. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1155255
Modern Language Association (MLA)
Zeng, Dao-Bing…[et al.]. The Effect of Splenectomy on the Reversal of Cirrhosis: a Prospective Study. Gastroenterology Research and Practice No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1155255
American Medical Association (AMA)
Zeng, Dao-Bing& Di, Liang& Zhang, Rui-Chi& Guo, Qing-Liang& Duan, Bin-Wei& Jia, Cui-Yu…[et al.]. The Effect of Splenectomy on the Reversal of Cirrhosis: a Prospective Study. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1155255
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155255