Effects of Qingshen Granules on the Oxidative Stress-NFkB Signal Pathway in Unilateral Ureteral Obstruction Rats
Joint Authors
Wang, Yiping
Zhang, Lei
Jin, Hua
Wang, Dong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The activation of NF-kappa B (NF/kB) signaling pathway plays an important role in the process of epithelial-mesenchymal transition (EMT) and renal interstitial fibrosis (RIF) in renal tubules.
The process of oxidative stress reaction in kidney is via excessive reactive oxygen species (ROS) production to activate NF/kB signaling pathway.
Qingshen Granule (QSG) is an effective Chinese formula utilized to treat chronic renal failure.
Previous studies confirmed that QSG could inhibit RIF in unilateral ureteral obstruction (UUO) rats.
In this study, we used UUO rats to investigate the effects of QSG on oxidative stress and the activation of NF/kB signaling.
Seventy male Sprague-Dawley (SD) rats were randomly divided into a sham group, UUO model group, Qingshen Granules (QSG) high-dose, medium-dose, and low-dose groups, PDTC group, and candesartan group (10 rats in each group).
Our study demonstrated that oxidative stress-NF/kB signal pathway contributed to the formation of UUO renal interstitial fibrosis.
QSG may protect against RIF by inhibiting the oxidative stress-NF/kB signal pathway, reducing inflammation, and improving renal tubular EMT.
American Psychological Association (APA)
Jin, Hua& Wang, Yiping& Wang, Dong& Zhang, Lei. 2018. Effects of Qingshen Granules on the Oxidative Stress-NFkB Signal Pathway in Unilateral Ureteral Obstruction Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155280
Modern Language Association (MLA)
Jin, Hua…[et al.]. Effects of Qingshen Granules on the Oxidative Stress-NFkB Signal Pathway in Unilateral Ureteral Obstruction Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1155280
American Medical Association (AMA)
Jin, Hua& Wang, Yiping& Wang, Dong& Zhang, Lei. Effects of Qingshen Granules on the Oxidative Stress-NFkB Signal Pathway in Unilateral Ureteral Obstruction Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155280