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Effects of a Portable Peritoneal Lavage Device on Dogs with Seawater-Immersed Open Abdominal Injury
Joint Authors
Zhou, Song
Nie, Kai
Zhang, Wenhua
Shao, Zhihong
Zhong, Wei
Ye, Qinglin
Lin, Xiaoqiang
Chen, Yuefeng
Wang, Xiaowen
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Seawater-immersed open abdominal injury is a special injury during marine activities.
Effective warmed peritoneal lavage in the field early after injury is the key to treatment.
This pilot study aimed at exploring the treatment effects of a self-developed portable peritoneal lavage device compared with conventional treatment model.
Material and Methods.
Beagle dogs were used to develop models of seawater-immersed open abdominal injury.
A conventional lavage method or a novel peritoneal lavage device was used for lavage and rewarming.
The vital signs, electrolyte, serum inflammatory cytokine expression levels, histological changes of mucosa, and microstructure variety of different groups were observed and compared before and after immersion and 2 h, 1 d, 3 d, and 5 d after lavage.
Results.
The levels of TNF-α, IL-1β, IL-8, IFN-γ, VEGF, and TGF-β in the blood and the damage of tissues and cells in three groups were increased after immersion and decreased at the later points of time after lavage.
The concentration of Na+, K+, Cl-, lactate, and lactate dehydrogenase in the plasma was significantly higher than that before immersion (P<0.05), and the concentration of Ca2+ and HCO3- and plasma pH decreased slightly (P<0.05).
The degree of tissue inflammation and mucosal injury in the delayed control group and device group was lower than the control group.
Conclusions.
Timely lavage and rewarming using a portable peritoneal lavage device reduced the inflammatory response of seawater-immersed open abdominal injury dogs and reduced the damage of multiple organs.
The dogs recovered better and faster than the conventional treatment group.
American Psychological Association (APA)
Zhou, Song& Nie, Kai& Zhang, Wenhua& Shao, Zhihong& Zhong, Wei& Ye, Qinglin…[et al.]. 2019. Effects of a Portable Peritoneal Lavage Device on Dogs with Seawater-Immersed Open Abdominal Injury. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1155303
Modern Language Association (MLA)
Zhou, Song…[et al.]. Effects of a Portable Peritoneal Lavage Device on Dogs with Seawater-Immersed Open Abdominal Injury. Gastroenterology Research and Practice No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1155303
American Medical Association (AMA)
Zhou, Song& Nie, Kai& Zhang, Wenhua& Shao, Zhihong& Zhong, Wei& Ye, Qinglin…[et al.]. Effects of a Portable Peritoneal Lavage Device on Dogs with Seawater-Immersed Open Abdominal Injury. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1155303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155303