Confirming the Effects of Qinghuayin against Chronic Atrophic Gastritis and a Preliminary Observation of the Involved Inflammatory Signaling Pathways: An In Vivo Study
Joint Authors
Li, Shunan
Asakawa, Tetsuya
Li, Sihan
Huang, Minghan
Chen, Qin
Wang, Xin
Lin, Jianlong
Zhong, Guodong
Lin, Ping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Qinghuayin (QHY) is a Chinese formula that is widely used in the treatment of chronic atrophic gastritis (CAG).
This study was planned with the following objectives: ( 1 ) confirming the efficacy of QHY in a rat model of CAG and ( 2 ) performing a preliminary observation of the changes in several inflammatory signaling pathways potentially involved in the QHY mechanisms.
Methods.
A total of 33 rats were used in this study; they were divided into the control (n = 12) and model (n = 21) groups.
QHY was administrated to both the groups.
We assessed the pathological manifestations and the serum tumor necrosis factor alpha (TNF-α) level as markers of efficacy.
We also performed a preliminary observation of the changes in the protein and messenger ribonucleic acid (mRNA) expression of toll-like receptors 4 (TLR4), MyD88, NF-κB, and COX-2.
Results.
The pathological changes induced in the rats by the establishment of the CAG models were recovered by low and high doses of QHY.
Their serum TNF-α level also reduced following low- and high-dose QHY treatment.
Protein and mRNA expressions of TLR4, MyD88, NF-κB, and COX-2 were upregulated by the establishment of CAG models and downregulated by the administration of low- and high-dose QHY.
Conclusions.
Our data confirm the efficacy of QHY as an adjuvant therapy, based on the theories in traditional Chinese medicine.
The preliminary observations indicate that the downregulation of the enhanced inflammatory signaling pathways might be crucial QHY mechanisms that need further verification.
American Psychological Association (APA)
Li, Sihan& Huang, Minghan& Chen, Qin& Li, Shunan& Wang, Xin& Lin, Jianlong…[et al.]. 2018. Confirming the Effects of Qinghuayin against Chronic Atrophic Gastritis and a Preliminary Observation of the Involved Inflammatory Signaling Pathways: An In Vivo Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155315
Modern Language Association (MLA)
Li, Sihan…[et al.]. Confirming the Effects of Qinghuayin against Chronic Atrophic Gastritis and a Preliminary Observation of the Involved Inflammatory Signaling Pathways: An In Vivo Study. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1155315
American Medical Association (AMA)
Li, Sihan& Huang, Minghan& Chen, Qin& Li, Shunan& Wang, Xin& Lin, Jianlong…[et al.]. Confirming the Effects of Qinghuayin against Chronic Atrophic Gastritis and a Preliminary Observation of the Involved Inflammatory Signaling Pathways: An In Vivo Study. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155315
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155315