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Serum Resolvin E1 Levels and Its Relationship with Disease Activity in Ulcerative Colitis
Joint Authors
Paköz, Zehra Betül
Günay, Süleyman
Taşova, Ferda
Yılmaz, Huriye Erbak
Cekic, Cem
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Resolvins originate from ω-3 PUFA (polyunsaturated fatty acid) precursors and play a role in the resolution of inflammation.
The aim of this study was to determine the serum Resolvin E1 levels in patients with ulcerative colitis (UC) and to evaluate the relationship between the serum Resolvin E1 levels and ulcerative colitis disease activity.
Methods.
In this observational study, serum samples were collected from 51 patients with UC and 30 healthy controls for the determination of Resolvin E1 levels.
Firstly, we compared the serum Resolvin E1 levels between the UC patients and the control group.
Subsequently, Resolvin E1 levels were analyzed in patients with active UC and UC in remission.
Finally, the correlation between Resolvin E1 and C-reactive protein (CRP) and partial Mayo score (p-MS) was analyzed to determine the efficacy of Resolvin E1 in predicting disease activity.
Results.
Serum Resolvin E1 level was determined in the UC group (3126±1413 ng/ml) and in the control group (2758±1065 ng/ml) (p=0.187).
Serum Resolvin E1 levels were determined in patients with active UC (3114±1166 ng/ml) and patients in remission (3132±1520 ng/ml) (p=0.749).
In the UC group, a low-grade positive significant association was found between Resolvin E1 and CRP (r=0.303, p=0.031).
There was no significant association between Resolvin E1 and partial Mayo score (r=−0.207, p=0.146).
Conclusions.
There was no sufficient evidence that Resolvin E1 was an appropriate inflammatory marker to determine disease activity in UC.
American Psychological Association (APA)
Günay, Süleyman& Taşova, Ferda& Yılmaz, Huriye Erbak& Paköz, Zehra Betül& Cekic, Cem. 2019. Serum Resolvin E1 Levels and Its Relationship with Disease Activity in Ulcerative Colitis. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1155323
Modern Language Association (MLA)
Günay, Süleyman…[et al.]. Serum Resolvin E1 Levels and Its Relationship with Disease Activity in Ulcerative Colitis. Gastroenterology Research and Practice No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1155323
American Medical Association (AMA)
Günay, Süleyman& Taşova, Ferda& Yılmaz, Huriye Erbak& Paköz, Zehra Betül& Cekic, Cem. Serum Resolvin E1 Levels and Its Relationship with Disease Activity in Ulcerative Colitis. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1155323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155323