Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis

Joint Authors

Xu, Huachong
Shi, Yucong
Wu, Sizhi
Pang, Peng
Deng, Li
Chen, Xiaoyin
Zheng, Ke

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-02-26

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

The objective of this study is to investigate the effects of baicalin on controlling the pulmonary infection and improving the prognosis in influenza A virus (IAV) infection.

PCR and western blot were used to measure the changes of some key factors in RLRs signaling pathway.

MSD electrochemiluminescence was used to measure the expression of pulmonary inflammatory cytokines including IFN-γ, TNF-α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p70, and KC/GRO.

Flow cytometry was used to detect the proportion of Th1, Th2, Th17, and Treg.

The results showed that IAV infection led to low body weight and high viral load and high expression of RIG-I, IRF3, IRF7, and NF-κB mRNA, as well as RIG-I and NF-κB p65 protein.

However, baicalin reduced the rate of body weight loss, inhibited virus replication, and downregulated the key factors of the RLRs signaling pathway.

Besides, baicalin reduced the high expression inflammatory cytokines in lung and decreased the ratios of Th1/Th2 and Th17/Treg to arouse a brief but not overviolent inflammatory response.

Therefore, baicalin activated a balanced host inflammatory response to limit immunopathologic injury, which was helpful to the improvement of clinical and survival outcomes.

American Psychological Association (APA)

Pang, Peng& Zheng, Ke& Wu, Sizhi& Xu, Huachong& Deng, Li& Shi, Yucong…[et al.]. 2018. Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155333

Modern Language Association (MLA)

Pang, Peng…[et al.]. Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1155333

American Medical Association (AMA)

Pang, Peng& Zheng, Ke& Wu, Sizhi& Xu, Huachong& Deng, Li& Shi, Yucong…[et al.]. Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155333

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1155333