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Capybara Oil Improves Hepatic Mitochondrial Dysfunction, Steatosis, and Inflammation in a Murine Model of Nonalcoholic Fatty Liver Disease
Joint Authors
Cortez, Erika
Vieira, Aline B.
Pereira, Priscila G.
Rabelo, Kíssila
Ciambarella, Bianca T.
Nascimento, Ana L. R.
Moura, Aníbal S.
Guimarães, Fernanda V.
Martins, Marco A.
Barquero, Gonzalo
de Carvalho, Jorge J.
Marinho, Polyana Cury
Neto-Ferreira, Rodrigo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) is recognized as the most common cause of liver dysfunction worldwide and is commonly associated with obesity.
Evidences suggest that NAFLD might be a mitochondrial disease, which contributes to the hepatic steatosis, oxidative stress, cytokine release, and cell death.
Capybara oil (CO) is a rich source of polyunsaturated fatty acids (PUFA), which is known to improve inflammation and oxidative stress.
In order to determine the effects of CO on NAFLD, C57Bl/6 mice were divided into 3 groups and fed a high-fat diet (HFD) (NAFLD group and NAFLD + CO group) or a control diet (CG group) during 16 weeks.
The CO (1.5 g/kg/daily) was administered by gavage during the last 4 weeks of the diet protocol.
We evaluated plasma liver enzymes, hepatic steatosis, and cytokine expression in liver as well as hepatocyte ultrastructural morphology and mitochondrial function.
CO treatment suppressed hepatic steatosis, attenuated inflammatory response, and decreased plasma alanine aminotransferase (ALT) in mice with NAFLD.
CO was also capable of restoring mitochondrial ultrastructure and function as well as balance superoxide dismutase and catalase levels.
Our findings indicate that CO treatment has positive effects on NAFLD improving mitochondrial dysfunction, steatosis, acute inflammation, and oxidative stress.
American Psychological Association (APA)
Marinho, Polyana Cury& Vieira, Aline B.& Pereira, Priscila G.& Rabelo, Kíssila& Ciambarella, Bianca T.& Nascimento, Ana L. R.…[et al.]. 2018. Capybara Oil Improves Hepatic Mitochondrial Dysfunction, Steatosis, and Inflammation in a Murine Model of Nonalcoholic Fatty Liver Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155354
Modern Language Association (MLA)
Marinho, Polyana Cury…[et al.]. Capybara Oil Improves Hepatic Mitochondrial Dysfunction, Steatosis, and Inflammation in a Murine Model of Nonalcoholic Fatty Liver Disease. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1155354
American Medical Association (AMA)
Marinho, Polyana Cury& Vieira, Aline B.& Pereira, Priscila G.& Rabelo, Kíssila& Ciambarella, Bianca T.& Nascimento, Ana L. R.…[et al.]. Capybara Oil Improves Hepatic Mitochondrial Dysfunction, Steatosis, and Inflammation in a Murine Model of Nonalcoholic Fatty Liver Disease. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155354