The Antioxidant Polysaccharide from Semiaquilegia adoxoides (DC.) Makino Adjusts the Immune Response of Mice Infected by Bacteria
Joint Authors
Yang, Yunqiao
Guo, Lei
Tariq, Kinza
Zhang, Weiyu
Li, Chong
Memon, Fareed Qamar
Chai, Beibei
Li, Zheng
Sun, Junying
Chen, Yunru
Zhang, Geyin
Li, Qinmei
Wang, Shuaiyang
Wang, Lizhen
Lai, Chongbo
Jiang, Mingsheng
Si, Hongbin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Semiaquilegia adoxoides (DC.) Makino is a herbal medicine and it is recorded that its water extract can be used to treat acute diseases caused by bacterial infections.
In order to understand the polysaccharide of Semiaquilegia adoxoides (DC.) Makino (SMP), FT-IR and HPLC methods were performed to determine the basic chemical structure and monosaccharide compositions of SMP.
The antioxidant capacity of SMP was analyzed by monitoring both the scavenging rate of DPPH and ABTS free radical.
To investigate the effects of SMP on the acute bacterial disease, minimum inhibitory concentrations (MICs) of SMP on E.
coli or S.
aureus were detected; meanwhile, mice were administrated with SMP for 7 days and then infected with E.
coli or S.
aureus, and the parameters were measured at the 9th day.
Results showed that SMP was a furanose which was mainly composed of glucose (60.3%) and had certain antioxidant activities.
Both MIC values of SMP on E.
coli and S.
aureus were 250 ml/mL, which means that SMP has no direct antibacterial effects.
The mice experiments revealed that SMP had potential effects on immunomodulatory by reducing WBC and the expression of serum IL-1, IL-6, and TNF-α and increasing IgM of E.
coli or S.
aureus infected mice.
These findings supported the effect of Semiaquilegia adoxoides (DC.) Makino in folk use with scientific evidence.
American Psychological Association (APA)
Yang, Yunqiao& Guo, Lei& Tariq, Kinza& Zhang, Weiyu& Li, Chong& Memon, Fareed Qamar…[et al.]. 2020. The Antioxidant Polysaccharide from Semiaquilegia adoxoides (DC.) Makino Adjusts the Immune Response of Mice Infected by Bacteria. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155370
Modern Language Association (MLA)
Yang, Yunqiao…[et al.]. The Antioxidant Polysaccharide from Semiaquilegia adoxoides (DC.) Makino Adjusts the Immune Response of Mice Infected by Bacteria. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1155370
American Medical Association (AMA)
Yang, Yunqiao& Guo, Lei& Tariq, Kinza& Zhang, Weiyu& Li, Chong& Memon, Fareed Qamar…[et al.]. The Antioxidant Polysaccharide from Semiaquilegia adoxoides (DC.) Makino Adjusts the Immune Response of Mice Infected by Bacteria. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155370