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The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis
Joint Authors
Liu, Ling
Lang, Junjie
Jin, Yuelong
Chen, Yan
Chang, Weiwei
Yao, Yingshui
Yu, Jiegen
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
The current gold standard for gastric cancer (GC) screening is pathology or a barium meal followed by X-ray.
This is not applicable to a wide range of screening capabilities due to the lack of operability.
This article used a meta-analysis to evaluate the value of pepsinogen (PG) screening for GC.
Methods.
PubMed, EMbase, the Cochrane Library, CNKI, WanFang, VIP, and CBM databases were systematically searched for published studies that used serum PG to diagnose GC.
Articles were searched from January 2003 to January 2018.
Two reviewers independently screened the literature according to specified inclusion and exclusion criteria.
The data were extracted and evaluated, and the quality of the methodologies evaluated using the QUADAS entry.
The meta-analysis (MA) was performed using Meta-DiSc 1.4 software.
Stata 12.0 software was used to assess publication bias.
Results.
A total of 19 studies were finally included from a total of 169,009 cases.
The MA showed a combined sensitivity and specificity of 0.56 (95% CI (0.53–0.59), P<0.01) and 0.71 (95% CI (0.70-0.71), P<0.01), respectively.
The combined likelihood ratios were +LR = 2.82 (95% CI (2.06–3.86), P<0.01) and −LR = 0.56 (95% CI (0.45–0.68), P<0.01).
The combined DOR was 5.41 (95% CI (3.64~ 8.06), P<0.01), and the area under the SROC curve was 0.7468.
Conclusions.
Serum PG provides medium levels of sensitivity and specificity for GC assessment.
To be used in a clinical setting, further high-quality research must be performed and verified.
American Psychological Association (APA)
Liu, Ling& Lang, Junjie& Jin, Yuelong& Chen, Yan& Chang, Weiwei& Yao, Yingshui…[et al.]. 2019. The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1155375
Modern Language Association (MLA)
Liu, Ling…[et al.]. The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1155375
American Medical Association (AMA)
Liu, Ling& Lang, Junjie& Jin, Yuelong& Chen, Yan& Chang, Weiwei& Yao, Yingshui…[et al.]. The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1155375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155375