![](/images/graphics-bg.png)
Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma
Joint Authors
Liang, Yufei
Zheng, Guoqi
Yin, Wenjie
Song, Hui
Li, Chunying
Tian, Liang
Yang, Dongliang
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
The aim of our study was to investigate the expression of EGFR and PTEN in tissues and measure the serum platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) to evaluate the prognostic factors of patients with epithelioid malignant peritoneal mesothelioma (MPeM).
Methods.
33 patients of pathologically diagnosed epithelioid MPeM tissues were analyzed using immunohistochemistry to detect EGFR and PTEN; the PLR and NLR were determined by using a routine blood test.
We analyzed the relationships of these markers to age, sex, asbestos exposure, elevated platelet count, ascites, and clinical stage.
Results.
EGFR and PTEN expressions were positive in 22 (66.67%) and 7 (21.21%) epithelioid MPeM patients, respectively.
However, these two markers as well as PLR and NLR were not significantly associated with age, sex, asbestos exposure, elevated platelet counts, ascites, and clinical stage (P>0.05).
The correlation between EGFR and PTEN was negative (r=−0.577, P<0.001), but the correlation between NLR and PLR was positive (r=0.456, P=0.008).
The median survival of all patients was 6 months.
In univariate analysis, PTEN (P<0.001), PLR (P=0.014), and NLR (P=0.015) affected the overall survival.
Multivariate analysis revealed that PTEN and PLR were validated as predictive for overall survival of epithelioid MPeM (HR=0.070, P=0.001, and HR=3.379, P=0.007, respectively).
Conclusion.
On the basis of these results, it is suggested that PTEN and PLR are risk factors for the prognosis of epithelioid MPeM, which may be targets for selective therapies and improve the outcomes of patients with epithelioid MPeM.
American Psychological Association (APA)
Liang, Yufei& Zheng, Guoqi& Yin, Wenjie& Song, Hui& Li, Chunying& Tian, Liang…[et al.]. 2019. Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1155377
Modern Language Association (MLA)
Liang, Yufei…[et al.]. Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma. Gastroenterology Research and Practice No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1155377
American Medical Association (AMA)
Liang, Yufei& Zheng, Guoqi& Yin, Wenjie& Song, Hui& Li, Chunying& Tian, Liang…[et al.]. Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1155377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155377