Up-to-Date Tailored Systemic Treatment in Pancreatic Ductal Adenocarcinoma
Joint Authors
Fong, Caroline Y. K.
Burke, Emma
Cunningham, David
Starling, Naureen
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-05
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Despite intensive research efforts, pancreatic ductal adenocarcinoma is still regarded as an aggressive and life-limiting malignancy.
Combination chemotherapy regimens that underpin the current treatment approach in the advanced setting have led to incremental survival gains in recent years but have failed to confer patients with a median overall survival that exceeds 12 months from diagnosis.
Research has since focussed on understanding the role and interplay between various components of the desmoplastic stroma and tumour microenvironment, in addition to developing targeted therapies based on molecular features to improve the prognosis associated with this malignancy.
This review will summarise the available systemic treatment options and discuss potential methods to refine the resolution of patient selection to enhance responses to currently available therapies.
Furthermore, it will explore newer approaches anticipated to come to the fore of future clinical practice, such as agents targeting the DNA damage response and tumour microenvironment as well as immunotherapy-based combinations.
American Psychological Association (APA)
Fong, Caroline Y. K.& Burke, Emma& Cunningham, David& Starling, Naureen. 2019. Up-to-Date Tailored Systemic Treatment in Pancreatic Ductal Adenocarcinoma. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1155384
Modern Language Association (MLA)
Fong, Caroline Y. K.…[et al.]. Up-to-Date Tailored Systemic Treatment in Pancreatic Ductal Adenocarcinoma. Gastroenterology Research and Practice No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1155384
American Medical Association (AMA)
Fong, Caroline Y. K.& Burke, Emma& Cunningham, David& Starling, Naureen. Up-to-Date Tailored Systemic Treatment in Pancreatic Ductal Adenocarcinoma. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1155384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155384