HLA Haplotype Association with Celiac Disease in Albanian Pediatric Patients from Kosovo
Joint Authors
Grubic, Zorana
Ramosaj-Morina, Atifete
Burek Kamenaric, Marija
Azemi, Mehmedali
Spahiu, Lidvana
Zunec, Renata
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Genetic predisposition to celiac disease (CD) is strongly associated with the presence of HLA alleles in the individual genotype encoding HLA-DQ2 and/or HLA-DQ8 heterodimers.
The main aim of this study was to analyze the HLA-A, -B, -DRB1, and -DQ allele and five-locus haplotype frequencies in 60 Albanian pediatric CD patients and 124 non-CD children from Kosovo.
The most prevalent haplotype in patients was the ancestral AH 8.1 haplotype present in 22.5% of the cases compared to 2.8% of the controls (P<0.0001).
Additionally, two other haplotypes were also overrepresented in patients (HLA-A∗02~B∗50~DRB1∗07~DQA1∗02:01~DQB1∗02:02 and HLA-A∗68~B∗44~DRB1∗07~DQA1∗02:01~DQB1∗02:02).
Analysis showed that 95.0% of CD patients and 43.3% of controls were carriers of HLA-DQ2 and/or HLA-DQ8 heterodimers.
The most frequent CD-predisposing HLA-DQ haplotypes in patients were HLA-DQ2.5 (46.7%) and HLA-DQ2.2 (11.6%), while the most prevalent genotypes were HLA-DQ2.5/DQX (58.3%) and HLA-DQ2.5/DQ2.2 (20.0%).
The frequency of the HLA-DQ8 heterodimer among CD patients (4.2%) compared to the control group (8.1%) was without statistical significance.
The given data demonstrate differences in the distribution of HLA haplotypes among Albanian CD patients from Kosovo in comparison to other European and non-European populations, as well as provide additional population data to supplement the thus far undisputed importance of the role of HLA-DQ2 and HLA-DQ8 heterodimers in the development of CD.
American Psychological Association (APA)
Ramosaj-Morina, Atifete& Burek Kamenaric, Marija& Azemi, Mehmedali& Spahiu, Lidvana& Grubic, Zorana& Zunec, Renata. 2019. HLA Haplotype Association with Celiac Disease in Albanian Pediatric Patients from Kosovo. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155391
Modern Language Association (MLA)
Ramosaj-Morina, Atifete…[et al.]. HLA Haplotype Association with Celiac Disease in Albanian Pediatric Patients from Kosovo. Gastroenterology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1155391
American Medical Association (AMA)
Ramosaj-Morina, Atifete& Burek Kamenaric, Marija& Azemi, Mehmedali& Spahiu, Lidvana& Grubic, Zorana& Zunec, Renata. HLA Haplotype Association with Celiac Disease in Albanian Pediatric Patients from Kosovo. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155391
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155391