Differential Regulation of NF-κB and Nrf2 by Bojungikki-Tang Is Associated with Suppressing Lung Inflammation
Joint Authors
Joo, Myungsoo
Choi, Jun-Yong
Kim, Kyun Ha
Won, Ran
Park, Soo Ryun
Kwun, Min Jung
Lee, Ji Yeon
Han, Chang Woo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Bojungikki-tang (BT), an Asian herbal remedy, has been prescribed to increase the vitality of debilitated patients.
Since a compromised, weakened vitality often leads to illness, BT has been widely used to treat various diseases.
However, little is known about the mechanism by which BT exerts its effect.
Given that BT ameliorates inflammatory pulmonary diseases including acute lung injury (ALI), we investigated whether BT regulates the function of key inflammatory factors such as NF-κB and Nrf2, contributing to suppressing inflammation.
Results show that BT interrupted the nuclear localization of NF-κB and suppressed the expression of the NF-κB-dependent genes in RAW 264.7 cells.
In similar experiments, BT induced the nuclear localization of Nrf2 and the expression of the Nrf2-dependent genes.
In a lipopolysaccharide-induced ALI mouse model, a single intratracheal administration of BT to mouse lungs ameliorated alveolar structure and suppressed the expression of proinflammatory cytokine genes and neutrophil infiltration to mouse lungs.
Therefore, our findings suggest that suppression of NF-κB and activation of Nrf2, by which BT suppresses inflammation, are ways for BT to exert its effect.
American Psychological Association (APA)
Park, Soo Ryun& Kim, Kyun Ha& Kwun, Min Jung& Lee, Ji Yeon& Won, Ran& Han, Chang Woo…[et al.]. 2018. Differential Regulation of NF-κB and Nrf2 by Bojungikki-Tang Is Associated with Suppressing Lung Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155392
Modern Language Association (MLA)
Park, Soo Ryun…[et al.]. Differential Regulation of NF-κB and Nrf2 by Bojungikki-Tang Is Associated with Suppressing Lung Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1155392
American Medical Association (AMA)
Park, Soo Ryun& Kim, Kyun Ha& Kwun, Min Jung& Lee, Ji Yeon& Won, Ran& Han, Chang Woo…[et al.]. Differential Regulation of NF-κB and Nrf2 by Bojungikki-Tang Is Associated with Suppressing Lung Inflammation. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155392
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155392