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Exploring the Pharmacological Mechanism of Danzhi Xiaoyao Powder on ER-Positive Breast Cancer by a Network Pharmacology Approach
Joint Authors
Zeng, Liuting
Yang, Kailin
Ge, Jinwen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-05
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Background.
Breast cancer is the most common malignancy among women worldwide, but the long-term endocrine therapy is frequently associated with adverse side effects.
Danzhi Xiaoyao powder (DXP) is a herbal formula that has an effect on breast cancer, especially ER-positive breast cancer.
However, the active compounds, potential targets, and pharmacological and molecular mechanism of its action against cancer remain unclear.
Methods.
A network pharmacology approach comprising drug-likeness evaluation, oral bioavailability prediction, Caco-2 permeability prediction, multiple compound target prediction, multiple known target collection, breast cancer genes collection, and network analysis has been used in this study.
Results.
Four networks are set up—namely, ER-positive breast cancer network, compound-compound target network of DXP, DXP-ER-positive breast cancer network, and compound-known target-ER-positive breast cancer network.
Some ER-positive breast cancer and DXP related targets, clusters, biological processes, and pathways, and several potential anticancer compounds are found.
Conclusion.
This network analysis successfully predicted, illuminated, and confirmed the molecular synergy of DXP for ER-positive breast cancer, got potential anticancer active compounds, and found the potential ER-positive breast cancer associated targets, cluster, biological processes, and pathways.
This work also provides clues to the researcher who explores ethnopharmacological or/and herbal medicine’s or even multidrugs’ various synergies.
American Psychological Association (APA)
Yang, Kailin& Zeng, Liuting& Ge, Jinwen. 2018. Exploring the Pharmacological Mechanism of Danzhi Xiaoyao Powder on ER-Positive Breast Cancer by a Network Pharmacology Approach. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1155397
Modern Language Association (MLA)
Yang, Kailin…[et al.]. Exploring the Pharmacological Mechanism of Danzhi Xiaoyao Powder on ER-Positive Breast Cancer by a Network Pharmacology Approach. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-20.
https://search.emarefa.net/detail/BIM-1155397
American Medical Association (AMA)
Yang, Kailin& Zeng, Liuting& Ge, Jinwen. Exploring the Pharmacological Mechanism of Danzhi Xiaoyao Powder on ER-Positive Breast Cancer by a Network Pharmacology Approach. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1155397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155397