Systems Pharmacology Dissection of Traditional Chinese Medicine Wen-Dan Decoction for Treatment of Cardiovascular Diseases
Joint Authors
Xu, Dan-Ping
Wu, Huan-Lin
Lan, Tao-Hua
Zhang, Lu-Lu
Wang, Yonghua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-10
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cardiovascular diseases (CVDs) have been recognized as first killer of human health.
The underlying mechanisms of CVDs are extremely complicated and not fully revealed, leading to a challenge for CVDs treatment in modern medicine.
Traditional Chinese medicine (TCM) characterized by multiple compounds and targets has shown its marked effects on CVDs therapy.
However, system-level understanding of the molecular mechanisms is still ambiguous.
In this study, a system pharmacology approach was developed to reveal the underlying molecular mechanisms of a clinically effective herb formula (Wen-Dan Decoction) in treating CVDs.
127 potential active compounds and their corresponding 283 direct targets were identified in Wen-Dan Decoction.
The networks among active compounds, targets, and diseases were built to reveal the pharmacological mechanisms of Wen-Dan Decoction.
A “CVDs pathway” consisted of several regulatory modules participating in therapeutic effects of Wen-Dan Decoction in CVDs.
All the data demonstrates that Wen-Dan Decoction has multiscale beneficial activity in CVDs treatment, which provides a new way for uncovering the molecular mechanisms and new evidence for clinical application of Wen-Dan Decoction in cardiovascular disease.
American Psychological Association (APA)
Lan, Tao-Hua& Zhang, Lu-Lu& Wang, Yonghua& Wu, Huan-Lin& Xu, Dan-Ping. 2018. Systems Pharmacology Dissection of Traditional Chinese Medicine Wen-Dan Decoction for Treatment of Cardiovascular Diseases. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1155436
Modern Language Association (MLA)
Lan, Tao-Hua…[et al.]. Systems Pharmacology Dissection of Traditional Chinese Medicine Wen-Dan Decoction for Treatment of Cardiovascular Diseases. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1155436
American Medical Association (AMA)
Lan, Tao-Hua& Zhang, Lu-Lu& Wang, Yonghua& Wu, Huan-Lin& Xu, Dan-Ping. Systems Pharmacology Dissection of Traditional Chinese Medicine Wen-Dan Decoction for Treatment of Cardiovascular Diseases. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1155436
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155436