Contemporary Tailored Oncology Treatment of Biliary Tract Cancers
Joint Authors
Cunningham, David
Starling, Naureen
Turkes, Fiona
Carmichael, Juliet
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-18
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Biliary tract cancers (BTCs) are poor prognosis malignancies with limited treatment options.
Capecitabine has recently emerged as an effective agent in the adjuvant setting; however, treatment of advanced disease is still limited to first-line cisplatin and gemcitabine chemotherapy.
Recent global efforts in genomic profiling and molecular subtyping of BTCs have uncovered a wealth of genomic aberrations which may carry prognostic significance and/or predict response to treatment, and several targeted agents have shown promising results in clinical trials.
As such, the uptake of comprehensive genomic profiling for patients with BTCs and the expansion of basket trials to include these patients are growing.
This review describes the currently approved systemic therapies for BTCs and provides insight into the emerging targeted and immunotherapeutic agents, as well as conventional chemotherapeutic regimes, currently being investigated in clinical trials.
American Psychological Association (APA)
Turkes, Fiona& Carmichael, Juliet& Cunningham, David& Starling, Naureen. 2019. Contemporary Tailored Oncology Treatment of Biliary Tract Cancers. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1155437
Modern Language Association (MLA)
Turkes, Fiona…[et al.]. Contemporary Tailored Oncology Treatment of Biliary Tract Cancers. Gastroenterology Research and Practice No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1155437
American Medical Association (AMA)
Turkes, Fiona& Carmichael, Juliet& Cunningham, David& Starling, Naureen. Contemporary Tailored Oncology Treatment of Biliary Tract Cancers. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1155437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155437