Herba Artemisiae Capillaris Extract Prevents the Development of Streptozotocin-Induced Diabetic Nephropathy of Rat
Joint Authors
Jin, Yingli
Zou, Yinggang
Yu, Xiao-yan
Geng, Jianan
Liu, Chunyu
Sun, Chengbo
Guo, Menghuan
Li, Zhen
Yu, Jinghua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is a major cause of end-stage renal disease throughout the world; until now there is no specific drug available.
In this work, we use herba artemisiae capillaris extract (HACE) to alleviate renal fibrosis characterized by the excessive accumulation of extracellular matrix (ECM) in rats, aiming to investigate the protective effect of the HACE on DN.
We found that the intragastric treatment of high-dose HACE could reverse the effect of streptozotocin not only to decrease the level of blood glucose and blood lipid in different degree but also further to improve renal functions.
It is worth mentioning that the effect of HACE treatment was comparable to the positive drug benazepril.
Moreover, we found that HACE treatment could on one hand inhibit oxidative stress in DN rats through regulating enzymatic activity for scavenging reactive oxygen species and on the other hand increase the ECM degradation through regulating the activity of metalloproteinase-2 (MMP-2) and the expression of tissue transglutaminase (tTG), which explained why HACE treatment inhibited ECM accumulation.
On the basis of above experimental results, we conclude that HACE prevents DN development in a streptozotocin-induced DN rat model, and HACE is a promising candidate to cure DN in clinic.
American Psychological Association (APA)
Geng, Jianan& Yu, Xiao-yan& Liu, Chunyu& Sun, Chengbo& Guo, Menghuan& Li, Zhen…[et al.]. 2018. Herba Artemisiae Capillaris Extract Prevents the Development of Streptozotocin-Induced Diabetic Nephropathy of Rat. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1155449
Modern Language Association (MLA)
Geng, Jianan…[et al.]. Herba Artemisiae Capillaris Extract Prevents the Development of Streptozotocin-Induced Diabetic Nephropathy of Rat. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1155449
American Medical Association (AMA)
Geng, Jianan& Yu, Xiao-yan& Liu, Chunyu& Sun, Chengbo& Guo, Menghuan& Li, Zhen…[et al.]. Herba Artemisiae Capillaris Extract Prevents the Development of Streptozotocin-Induced Diabetic Nephropathy of Rat. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1155449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155449