Efficacy and Safety of Aidi Injection as an Adjuvant Therapy on Advanced Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Joint Authors
Wen, Li
Chai, Yihui
Zhong, Qin
Gao, Jie
Guan, Liancheng
Zhang mengzhi, Liancheng
Huaiquan, Liu
Haiyang, Yu
Qingxue, Wang
Changfu, Yang
Chen, Yunzhi
Jiang, Zhibin
Ge, Yuhong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Aidi injection (ADI) is being used widely for breast cancer in China.
However, the efficacy and safety of it need to be summarized.
We conducted a systematic review and meta-analysis to compare ADI and non-ADI treatment for advanced breast cancer.
Methods.
We searched PubMed, EMBASE, CNKI, SinoMed, and CENTRAL from inception to Jan 2020 for randomized controlled trials (RCTs) with diagnosis of advanced breast cancer that compared the efficacy of ADI with non-ADI treatment.
Two researchers screened the literature, extracted data, and evaluated risk of bias separately.
The primary outcomes were overall response rate (ORR) and disease control rate (DCR).
The secondary outcomes included the QOL, immune cells, and adverse events.
Review Manager software was used for estimating risks of bias of included studies, data analysis, and plotting.
The sensitivity analysis and the publication bias test were performed using the R language.
I2 and chi-square tests were used to estimate heterogeneity.
If P>0.1 or I2 < 40%, the fixed-effect model meta-analysis was performed.
A random or fixed-effect analysis was used depending on the heterogeneity testing.
Weighted mean difference (WMD) or standard mean difference (SMD) was used for analysis of continuous data, and the rate ratio (RR) was calculated for the dichotomous variable, respectively.
Results.
We included 14 studies with 1006 patients diagnosed as advanced breast cancer in total.
The pooled effect showed that ADI increased ORR in advanced BC patients as an add-on therapy with little heterogeneity (RR = 1.14, 95% CI 1.03–1.27).
DCR in BC patients could not be improved by ADI.
ADI improved the KPS score in BC patients compared with chemotherapy alone (MD = 3.26, 95% CI 1.74–4.78).
There were no improvements on immune markers except CD4/CD8 and NK%.
Serum tumor markers CEA and CA153 were decreased while treated with ADI, but only one trial was involved.
ADI decreased the numbers of myelosuppression in advanced BC patients, and AST, ALT, γ-GT, and CK-MB were all decreased.
The sensitivity evaluation indicated that the result of the pooled effect size had good stability.
Conclusion.
This meta-analysis suggested that based on the existing evidence, treatment with ADI significantly changed the ORR of patients with advanced BC and improved their quality of life with few side effects.
However, more randomized trials involving larger samples should be considered, and detailed mechanisms are needed to be uncovered.
American Psychological Association (APA)
Chai, Yihui& Chen, Yunzhi& Wen, Li& Zhong, Qin& Gao, Jie& Jiang, Zhibin…[et al.]. 2020. Efficacy and Safety of Aidi Injection as an Adjuvant Therapy on Advanced Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155452
Modern Language Association (MLA)
Chai, Yihui…[et al.]. Efficacy and Safety of Aidi Injection as an Adjuvant Therapy on Advanced Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1155452
American Medical Association (AMA)
Chai, Yihui& Chen, Yunzhi& Wen, Li& Zhong, Qin& Gao, Jie& Jiang, Zhibin…[et al.]. Efficacy and Safety of Aidi Injection as an Adjuvant Therapy on Advanced Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155452