Effect of Rosa laevigata on PM10-Induced Inflammatory Response of Human Lung Epithelial Cells
Joint Authors
Kim, Yumi
Ko, Hyun Min
Choi, Seung-Han
An, Eun-Jin
Lee, Seung-Hyeon
Kim, Kwanil
Jang, Hyeung-Jin
Jung, Hee-Jae
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Particulate matter 10 (PM10) with a diameter of less than 10 mm causes inflammation and allergic reactions in the airways and lungs, which adversely affects asthmatic patients.
In this study, we examined the anti-inflammatory effects of Rosa laevigata (RL), which has been previously investigated medicinally in Korea and China for the discovery of plant-derived anti-inflammatory agents with low side effects, using a PM10-induced lung inflammatory disease model.
Using MTT assay, we confirmed that in A549 cells pretreated with RL, cytotoxicity induced by PM10 (100 μg/mL) exposure was attenuated.
In addition, western blotting revealed that RL suppressed the expression level of MAPK/NF-κB pathways and its downstream signal, COX-2 in PM10-induced A549 cells.
Moreover, real-time PCR demonstrated that RL downregulated the mRNA expression level of inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-13, and IL-17) in PM10-induced A549 cells.
Based on the results of this study, RL has been shown to relieve inflammation in the lungs due to PM10 exposure.
Therefore, RL may be developed as a natural remedy for respiratory diseases caused by PM10 exposure.
American Psychological Association (APA)
Ko, Hyun Min& Choi, Seung-Han& Kim, Yumi& An, Eun-Jin& Lee, Seung-Hyeon& Kim, Kwanil…[et al.]. 2020. Effect of Rosa laevigata on PM10-Induced Inflammatory Response of Human Lung Epithelial Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1155463
Modern Language Association (MLA)
Ko, Hyun Min…[et al.]. Effect of Rosa laevigata on PM10-Induced Inflammatory Response of Human Lung Epithelial Cells. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1155463
American Medical Association (AMA)
Ko, Hyun Min& Choi, Seung-Han& Kim, Yumi& An, Eun-Jin& Lee, Seung-Hyeon& Kim, Kwanil…[et al.]. Effect of Rosa laevigata on PM10-Induced Inflammatory Response of Human Lung Epithelial Cells. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1155463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155463