lncRNA Mirt2 Is Downregulated in Ulcerative Colitis and Regulates IL-22 Expression and Apoptosis in Colonic Epithelial Cells
Joint Authors
Ding, Guangrong
Ming, Yuzheng
Zhang, Yuling
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
lncRNA Mirt2 is a lipopolysaccharide- (LPS-) inducible inflammation inhibitor.
We found that Mirt2 was downregulated in plasma of ulcerative colitis (UC) patients and the downregulation of Mirt2 distinguished UC patients from healthy controls.
IL-22 was also downregulated in UC patients and positively correlated with Mirt2.
Mirt2 overexpression led to upregulated, while Mirt2 siRNA silencing led to inhibited secretion of IL-22 from colonic epithelial cells treated with LPS.
In addition, under LPS treatment, Mirt2 overexpression led to decreased, while Mirt2 siRNA silencing led to increased apoptotic rate of colonic epithelial cells.
Therefore, Mirt2 is downregulated in ulcerative colitis and regulates IL-22 expression in colonic epithelial cells.
American Psychological Association (APA)
Ding, Guangrong& Ming, Yuzheng& Zhang, Yuling. 2019. lncRNA Mirt2 Is Downregulated in Ulcerative Colitis and Regulates IL-22 Expression and Apoptosis in Colonic Epithelial Cells. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1155466
Modern Language Association (MLA)
Ding, Guangrong…[et al.]. lncRNA Mirt2 Is Downregulated in Ulcerative Colitis and Regulates IL-22 Expression and Apoptosis in Colonic Epithelial Cells. Gastroenterology Research and Practice No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1155466
American Medical Association (AMA)
Ding, Guangrong& Ming, Yuzheng& Zhang, Yuling. lncRNA Mirt2 Is Downregulated in Ulcerative Colitis and Regulates IL-22 Expression and Apoptosis in Colonic Epithelial Cells. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1155466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155466
