Potential Effects of Antioxidant and Serum Cholesterol-Lowering Effects of Gynura bicolor Water Extracts in Syrian Hamster
Joint Authors
Tsai, Pi-Jen
Hsieh, Shu-Ling
Liu, Ya-Ching
Wu, Chih-Chung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Gynura bicolor (Roxb.
and Willd.) DC (G.
bicolor) is a dietary vegetable in the Far East.
The aims of the present study were to investigate the antioxidant effects of the G.
bicolor water extract (GBWE) and its ability to regulate the blood lipid and lipoprotein profiles.
In this study, the pigment composition and antioxidant ability of the GBWE were analyzed.
Syrian hamsters were fed a high-fat diet (HFD) and the GBWE for 12 weeks, and the blood lipid levels, lipoprotein profiles, and cholesterol metabolism-related enzyme levels were then examined.
The results showed that the GBWE exhibited excellent 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity and ferrous-ion-chelating ability.
The hepatic glutathione levels in the hamsters were increased after the administration of low (0.4 g/kg BW, GBWE-L) or high (0.8 g/kg BW, GBWE-H) levels of the GBWE.
The GBWE-H-treated hamsters exhibited significantly decreased serum levels of total cholesterols (TC) and low-density lipoprotein-cholesterol (LDL-C) and significantly increased levels of lectin-cholesterol acetyltransferase (LCAT).
These results showed that GBWE-H can reduce the total cholesterol and LDL-C levels in HFD-fed hamsters, and this reduction might be involved in the regulation of LCAT expression.
American Psychological Association (APA)
Hsieh, Shu-Ling& Tsai, Pi-Jen& Liu, Ya-Ching& Wu, Chih-Chung. 2020. Potential Effects of Antioxidant and Serum Cholesterol-Lowering Effects of Gynura bicolor Water Extracts in Syrian Hamster. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155467
Modern Language Association (MLA)
Hsieh, Shu-Ling…[et al.]. Potential Effects of Antioxidant and Serum Cholesterol-Lowering Effects of Gynura bicolor Water Extracts in Syrian Hamster. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1155467
American Medical Association (AMA)
Hsieh, Shu-Ling& Tsai, Pi-Jen& Liu, Ya-Ching& Wu, Chih-Chung. Potential Effects of Antioxidant and Serum Cholesterol-Lowering Effects of Gynura bicolor Water Extracts in Syrian Hamster. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155467
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155467