Phytoceuticals in Acute Pancreatitis: Targeting the Balance between Apoptosis and Necrosis
Joint Authors
Gilca, Marilena
Dragos, Dorin
Gaman, Laura
Vlad, Adelina
Robu, Georgiana Catalina
Radoi, Mugurel Petrinel
Stroica, Laura
Badea, Mihaela
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-04
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
Despite recent advances in understanding the complex pathogenesis of pancreatitis, the management of the disease remains suboptimal.
The use of phytoceuticals (plant-derived pleiotropic multitarget molecules) represents a new research trend in pancreatology.
The purpose of this review is to discuss the phytoceuticals with pancreatoprotective potential in acute pancreatitis and whose efficacy is based, at least in part, on their capacity to modulate the acinar cell death.
The phytochemicals selected, belonging to such diverse classes as polyphenols, flavonoids, lignans, anthraquinones, sesquiterpene lactones, nitriles, and alkaloids, target the balance between apoptosis and necrosis.
Activation of apoptosis via various mechanisms (e.g., inhibition of X-linked inhibitor of apoptosis proteins by embelin, upregulation of FasL gene expression by resveratrol) and/or inhibition of necrosis seem to represent the essential key for decreasing the severity of the disease.
Apart from targeting the apoptosis/necrosis balance, the phytochemicals displayed other specific protective activities: inhibition of inflammasome (e.g., rutin), suppression of neutrophil infiltration (e.g., ligustrazine, resveratrol), and antioxidant activity.
Even though many of the selected phytoceuticals represent a promising therapeutic alternative, there is a shortage of human evidence, and further studies are required to provide solid basis to justify their use in the treatment of pancreatitis.
American Psychological Association (APA)
Gaman, Laura& Dragos, Dorin& Vlad, Adelina& Robu, Georgiana Catalina& Radoi, Mugurel Petrinel& Stroica, Laura…[et al.]. 2018. Phytoceuticals in Acute Pancreatitis: Targeting the Balance between Apoptosis and Necrosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-27.
https://search.emarefa.net/detail/BIM-1155469
Modern Language Association (MLA)
Gaman, Laura…[et al.]. Phytoceuticals in Acute Pancreatitis: Targeting the Balance between Apoptosis and Necrosis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-27.
https://search.emarefa.net/detail/BIM-1155469
American Medical Association (AMA)
Gaman, Laura& Dragos, Dorin& Vlad, Adelina& Robu, Georgiana Catalina& Radoi, Mugurel Petrinel& Stroica, Laura…[et al.]. Phytoceuticals in Acute Pancreatitis: Targeting the Balance between Apoptosis and Necrosis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-27.
https://search.emarefa.net/detail/BIM-1155469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155469