Anti-Inflammatory and Antioxidant Effects of Kelong-Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats
Joint Authors
Yan, Miao
Zhang, Ling
Fan, Xin-rong
Xie, Hui
He, Qing-Hu
Nie, Yu-Song
Zhang, Min
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Benign prostatic hyperplasia (BPH) is a common disease in the current ageing male population.
This research aims to study the effects of Kelong-Capsules (KLC) on testosterone-induced BPH.
Thirty rats were randomly divided into normal group, model group, and three treatment groups.
Three treatment groups were given KLC (3.6 g/kg), KLC (7.2 g/kg), and finasteride (0.9 mg/kg), respectively, for 28 days after establishing the animal model.
The BPH rat models were evaluated by Traditional Chinese Medicine (TCM) symptoms and prostate index (PI).
Results indicated that three treatment groups all alleviated the pathological changes of prostate and kidney at different levels.
Compared with the model group, the PI of the groups treated with KLC (7.2 g/kg) and finasteride decreased significantly.
The expressions of NF-E2 related factor 2 (Nrf-2) and quinine oxidoreductase (NQO1) in the group treated with KLC (3.6 g/kg) increased markedly (p<0.01).
The cyclooxygenase-2 (COX-2) protein expression of the group treated with KLC (7.2 g/kg) was increased (p<0.01).
In conclusion, KLC could obviously inhibit the growth of prostate, and KLC (3.6 g/kg) could promote the expressions of Nrf2 and NQO1.
American Psychological Association (APA)
Zhang, Ling& Fan, Xin-rong& Xie, Hui& He, Qing-Hu& Nie, Yu-Song& Zhang, Min…[et al.]. 2018. Anti-Inflammatory and Antioxidant Effects of Kelong-Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155473
Modern Language Association (MLA)
Zhang, Ling…[et al.]. Anti-Inflammatory and Antioxidant Effects of Kelong-Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1155473
American Medical Association (AMA)
Zhang, Ling& Fan, Xin-rong& Xie, Hui& He, Qing-Hu& Nie, Yu-Song& Zhang, Min…[et al.]. Anti-Inflammatory and Antioxidant Effects of Kelong-Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155473