Narrow-Band Imaging Colonoscopy to Assess Mucosal Angiogenesis in Ulcerative Colitis
Joint Authors
Guo, Tao
Qian, Jia-Ming
Yang, Ai-Ming
Li, Yue
Zhou, Wei-Xun
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aim.
It has been documented that angiogenesis is a largely unstudied component of the pathogenesis of ulcerative colitis (UC).
Under narrow-band imaging (NBI) colonoscopy, the mucosal vascular pattern (MVP) can be visualized without the use of dyes.
The aim of this study was to assess the grade of mucosal angiogenesis based on the MVP in UC.
Methods.
A total of 119 colorectal segments taken from 42 patients with UC were observed using NBI colonoscopy.
The MVP was classified as follows: clear, obscure, or absent.
Quantification of the degree of inflammation was performed using histological colitis scoring.
Potent angiogenic activity was assessed by immunohistochemical staining for vascular endothelial growth factor (VEGF).
Microvascular density was assessed using vessel counts as revealed by CD31 staining.
The correlation between the MVP and histological grades of inflammation and angiogenesis was evaluated.
Results.
The MVP correlated well with the histological severity of inflammation.
We also demonstrated an increasing level of microvascular density and VEGF staining along with the ordered types of MVPs.
In addition, a statistically strong association existed between microvascular density and VEGF staining.
Conclusions.
NBI colonoscopy might be a useful tool for the in vivo assessment of the grade of mucosal angiogenesis in UC.
American Psychological Association (APA)
Guo, Tao& Qian, Jia-Ming& Yang, Ai-Ming& Li, Yue& Zhou, Wei-Xun. 2019. Narrow-Band Imaging Colonoscopy to Assess Mucosal Angiogenesis in Ulcerative Colitis. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155479
Modern Language Association (MLA)
Guo, Tao…[et al.]. Narrow-Band Imaging Colonoscopy to Assess Mucosal Angiogenesis in Ulcerative Colitis. Gastroenterology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1155479
American Medical Association (AMA)
Guo, Tao& Qian, Jia-Ming& Yang, Ai-Ming& Li, Yue& Zhou, Wei-Xun. Narrow-Band Imaging Colonoscopy to Assess Mucosal Angiogenesis in Ulcerative Colitis. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155479