The Potential Effect of Chinese Herbal Formula Hongqijiangzhi Fang in Improving NAFLD: Focusing on NLRP3 Inflammasome and Gut Microbiota
Joint Authors
Yang, Qin-He
Zhang, Yu-Pei
Deng, Yuanjun
Tang, Kairui
Liang, Shu
He, Yifang
Liang, Yinji
Liang, Zien
Chen, Yanning
Chen, Runsen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The present study investigates the potential therapeutic mechanism underlying the effects of the Chinese herbal formula Hongqijiangzhi Fang (HJF) on nonalcoholic fatty liver disease (NAFLD) in rats.
Male Sprague Dawley (SD) rats were randomly divided into 4 groups (n=8): control group was fed a normal diet, three other groups were fed high-fat diets (HFD), and the two treatment groups were intragastrically given a compound probiotic or HJF during the molding time.
After 16 w, related indices were detected.
The results showed that HJF significantly reduced abdominal aorta serum cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), IL-1β, and IL-18, portal venous serum lipopolysaccharide (LPS), and liver TC and TG levels in HFD-fed rats.
HJF ameliorated hepatic steatosis in the liver and improved the intestinal barrier in HFD-fed rats.
Activation of the NLRP3 inflammasome was reduced by HJF in HFD-fed rats.
Additionally, the abundances of A.
muciniphila (Verrucomicrobiaceae), F.
rappini (Helicobacteraceae), and Enterobacteriaceae bacteria significantly decreased in HJF-treated HFD-fed rats.
In conclusion, these result suggested that the Chinese herbal formula HJF reduced hepatic steatosis maybe through decreasing certain gut bacteria (such as Enterobacteriaceae bacteria and F.
rappini), alleviating intestinal endotoxemia and reducing NLRP3 inflammasome activation.
American Psychological Association (APA)
Liang, Shu& Zhang, Yu-Pei& Deng, Yuanjun& He, Yifang& Liang, Yinji& Liang, Zien…[et al.]. 2018. The Potential Effect of Chinese Herbal Formula Hongqijiangzhi Fang in Improving NAFLD: Focusing on NLRP3 Inflammasome and Gut Microbiota. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1155511
Modern Language Association (MLA)
Liang, Shu…[et al.]. The Potential Effect of Chinese Herbal Formula Hongqijiangzhi Fang in Improving NAFLD: Focusing on NLRP3 Inflammasome and Gut Microbiota. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1155511
American Medical Association (AMA)
Liang, Shu& Zhang, Yu-Pei& Deng, Yuanjun& He, Yifang& Liang, Yinji& Liang, Zien…[et al.]. The Potential Effect of Chinese Herbal Formula Hongqijiangzhi Fang in Improving NAFLD: Focusing on NLRP3 Inflammasome and Gut Microbiota. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1155511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155511