Oral Phosphatidylcholine Improves Intestinal Barrier Function in Drug-Induced Liver Injury in Rats
Joint Authors
Fan, Xue-Gong
Chen, Meijuan
Huang, Haijun
Zhou, Pengcheng
Zhang, Jiajie
Dai, Yining
Yang, Danhong
Pan, Hongying
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Phosphatidylcholine (PC) is the major surface-active phospholipid and creates a hydrophobic nature to the surface.
It has been reported to reverse the progression of liver fibrosis and to improve liver function.
The aim of the present study was to evaluate the effects of orally administered PC on intestinal barrier function (IBF) in rats with drug-induced liver injury.
Method.
Rats with carbon tetrachloride- (CCl4-) induced liver injury were treated with 100 mg/kg PC once daily for 21 days.
The effects of PC therapy on (i) liver function and portal pressure, (ii) intestinal and hepatic histology, and (iii) plasma endotoxin, diamine oxidase (DAO), and tumour necrosis factor- (TNF-) α levels were investigated.
Results.
PC therapy reduced portal pressure and improved the liver function in CCl4-induced liver injury.
In PC-treated liver injury rats, collagen fibres were gradually decreased, while the disordered arrangement of hepatocytes and disorganized hepatic lobules were partially repaired, and inflammatory cell infiltration was decreased in the fibrous tissue.
Lower inflammatory cell infiltration in the ileum improved intestinal histology, and reduced serum DAO levels were observed in PC-treated cirrhotic rats.
These changes were associated with reduced inflammatory activity, as indicated by decreased serum TNF-α levels and plasma endotoxin levels.
Conclusions.
These results suggest that PC therapy is hepatoprotective and is able to restore IBF and reduce endotoxaemia in rats with drug-induced liver injury.
American Psychological Association (APA)
Chen, Meijuan& Huang, Haijun& Zhou, Pengcheng& Zhang, Jiajie& Dai, Yining& Yang, Danhong…[et al.]. 2019. Oral Phosphatidylcholine Improves Intestinal Barrier Function in Drug-Induced Liver Injury in Rats. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1155530
Modern Language Association (MLA)
Chen, Meijuan…[et al.]. Oral Phosphatidylcholine Improves Intestinal Barrier Function in Drug-Induced Liver Injury in Rats. Gastroenterology Research and Practice No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1155530
American Medical Association (AMA)
Chen, Meijuan& Huang, Haijun& Zhou, Pengcheng& Zhang, Jiajie& Dai, Yining& Yang, Danhong…[et al.]. Oral Phosphatidylcholine Improves Intestinal Barrier Function in Drug-Induced Liver Injury in Rats. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1155530
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155530