Meta-Analysis of Antinuclear Antibodies in the Diagnosis of Antimitochondrial Antibody-Negative Primary Biliary Cholangitis
Joint Authors
Jia, Ji-Dong
You, Hong
Liu, Zhi-qiang
Zhang, Qian
Wu, Shanshan
Duan, Weijia
Chen, Sha
Ou, Xiaojuan
Kong, Yuanyuan
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
The diagnostic value of antinuclear antibodies (ANAs) including anti-gp210 and anti-sp100 for primary biliary cholangitis/cirrhosis (PBC) has been widely reported.
However, their diagnostic performances for antimitochondrial antibody- (AMA-) negative PBC were less well elucidated.
Therefore, the aim of the current meta-analysis was to evaluate the diagnostic accuracy of ANAs in patients with AMA-negative PBC.
Materials and Methods.
Literature on the diagnostic value of biomarkers for AMA-negative PBC was systematically searched in PubMed, MEDLINE, EMBASE, and the Cochrane Library.
The qualities of the retrieved studies were assessed by the Quality Assessment of Diagnostic Accuracy Studies-version 2 (QUADAS-2) scale.
Pooled sensitivity and specificity of the biomarkers were calculated with random-effects models.
The areas under the summary receiver operating characteristic (AUSROC) curves were used to evaluate the overall diagnostic performance of ANAs.
Results.
A total of 11 studies (400 AMA-negative PBC patients and 6217 controls) were finally included in the meta-analysis.
ANAs had an overall sensitivity of 27% (95% CI: 20%, 35%) and specificity of 98% (95% CI: 97%, 99%).
The pooled sensitivities for anti-gp210 and anti-sp100 were 23% (95% CI: 13%, 37%) and 25% (95% CI: 13%, 43%), respectively, and their specificities were 99% (95% CI: 97%, 100%) and 97% (95% CI: 93%, 98%), respectively.
Conclusions.
ANAs exhibited high specificity but low sensitivity and therefore could be used as reliable biomarkers to reduce the necessity of liver histology.
American Psychological Association (APA)
Zhang, Qian& Liu, Zhi-qiang& Wu, Shanshan& Duan, Weijia& Chen, Sha& Ou, Xiaojuan…[et al.]. 2019. Meta-Analysis of Antinuclear Antibodies in the Diagnosis of Antimitochondrial Antibody-Negative Primary Biliary Cholangitis. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1155539
Modern Language Association (MLA)
Zhang, Qian…[et al.]. Meta-Analysis of Antinuclear Antibodies in the Diagnosis of Antimitochondrial Antibody-Negative Primary Biliary Cholangitis. Gastroenterology Research and Practice No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1155539
American Medical Association (AMA)
Zhang, Qian& Liu, Zhi-qiang& Wu, Shanshan& Duan, Weijia& Chen, Sha& Ou, Xiaojuan…[et al.]. Meta-Analysis of Antinuclear Antibodies in the Diagnosis of Antimitochondrial Antibody-Negative Primary Biliary Cholangitis. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1155539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155539