Metabolomics-Based Clinical Efficacy and Effect on the Endogenous Metabolites of Tangzhiqing Tablet, a Chinese Patent Medicine for Type 2 Diabetes Mellitus with Hypertriglyceridemia
Joint Authors
Baohe, Wang
Yanfen, Li
Ziqiang, Li
Deqin, Zhang
Liu, Jia
Liu, Hua
Wang, Xianhua
Lv, Chunxiao
Wang, Ruihua
Li, Yan
Du, Xi
Yuhong, Huang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Tangzhiqing tablet (TZQ) is derived from Tangzhiqing formula, which has been used to regulate glucose and lipid metabolism in China for hundreds of years.
However, as a new Chinese patent medicine, its clinical indication is not clear.
To explore the clinical indication and effect on the patients with type 2 diabetes mellitus (T2DM), a pilot clinical trial and metabolomics study were carried out.
In the clinical study, T2DM patients were divided into three groups and treated with TZQ, placebo, or acarbose for 12 weeks, respectively.
The metabolomic study based on UPLC Q-TOF MS was performed including patients with hypertriglyceridemia in TZQ and placebo groups and healthy volunteers.
The clinical results showed that TZQ could reduce glycosylated hemoglobin (HbA1c) and fasting insulin.
For patients with hypertriglyceridemia in TZQ group, the levels of HbA1c all decreased and were correlated with the baseline level of triglyceride.
Metabonomics data showed a significant difference between patients and healthy volunteers, and 17 biomarkers were identified.
After 12-week treatment with TZQ, 11 biomarkers decreased significantly (p<0.05), suggesting that TZQ could improve the metabolomic abnormalities in these participants.
In conclusion, the clinical indication of TZQ was T2DM with hypertriglyceridemia, and its target was related to glycerophospholipid metabolism.
American Psychological Association (APA)
Liu, Jia& Ziqiang, Li& Liu, Hua& Wang, Xianhua& Lv, Chunxiao& Wang, Ruihua…[et al.]. 2018. Metabolomics-Based Clinical Efficacy and Effect on the Endogenous Metabolites of Tangzhiqing Tablet, a Chinese Patent Medicine for Type 2 Diabetes Mellitus with Hypertriglyceridemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155545
Modern Language Association (MLA)
Liu, Jia…[et al.]. Metabolomics-Based Clinical Efficacy and Effect on the Endogenous Metabolites of Tangzhiqing Tablet, a Chinese Patent Medicine for Type 2 Diabetes Mellitus with Hypertriglyceridemia. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1155545
American Medical Association (AMA)
Liu, Jia& Ziqiang, Li& Liu, Hua& Wang, Xianhua& Lv, Chunxiao& Wang, Ruihua…[et al.]. Metabolomics-Based Clinical Efficacy and Effect on the Endogenous Metabolites of Tangzhiqing Tablet, a Chinese Patent Medicine for Type 2 Diabetes Mellitus with Hypertriglyceridemia. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155545